Supplement Figure 1, Pretreatment with GBE has no significant effects on chronic high-glucose- induced AP-1 and NF-  B activation in HEACs. Glucose (25.

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Supplement Figure 1, Pretreatment with GBE has no significant effects on chronic high-glucose- induced AP-1 and NF-  B activation in HEACs. Glucose (25 mM) Mannitol (25 mM) GBE (100  g/ml) NAC (1 mM) Staurosporine (100 nM) Glucose (25 mM) Mannitol (25 mM) GBE (100  g/ml) NAC (1 mM) Staurosporine (10 nM) AP-1 NF-  B Staurosporine, a PKC inhibitor.

Supplement Figure 2, Pretreatment with GBE does-dependently suppressed high glucose-induced ICAM-1 accumulation in HAECs.

Supplement Figure 3, Endothelial ICAM-1 expression was increased by high-glucose (25mM) stimulation for 4 days, which was losing after the replacement of normal glucose medium (5mM) for 1-4 days.