Cimetidine Anatomy Physiology Chemistry Pharmacology Neural effects

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Presentation transcript:

Cimetidine Anatomy Physiology Chemistry Pharmacology Neural effects Cholinerigic Development Stomach cells Gastrin Synthesis Histamine QSAR Antacids Acid secretion Zollinger Ellison Histamine receptors Imidazole NSAID Aspirin Proton pump inhibitors Cimetidine H2 Antagonists Pharmaceutics Pathology Ulcers Dyspepsia Pharmacokinetics Formulation Helicobacta Clinical trials Doses Metabolism removal Misoprostol Therapeutic index Interactions Cytochrome P450 Liver Side effects Cautions Kidney Practice Biochemistry

Dyspepsia Neural effects Cholinerigic Cimetidine Gastrin Famotidine Acid secretion Histamine receptors Histamine Nizatidine H2 Antagonists Antacids Stomach cells Acid reflux GORD Zollinger Ellison Ranitidine Antibiotics Helicobacta Dyspepsia Gastric ulcers Proton pump inhibitors Duodenal ulcers Aspirin Duodenitis Gastritis Gastric cancer Hernia Calcium antagonists NSAID Endoscopy Misoprostol Angina Nausia Corticosteroids Vomiting

Acid secretion Parasympathetic NS Vagus nerve Zollinger Ellison Misoprostol Cholinerigic receptors Somatostatin. G cells ECL cells Cholecystokinin Gastrin Histamine D cells Histamine receptors Parietal cells Proton pump inhibitors NSAID Aspirin Acid secretion H2 Antagonists Dyspepsia Cimetidine Omeprazole Hydrochloric acid Ranitidine H+/K+ ATPase, pH Ulcers Helicobacta Pepsin Bicarbonate Antacids Famotidine Gastric mucosa. Achlorhydria Hypercalcaemia

Development QSAR Histamine Competitive antagonist Burimamide Metiamide Antihistamines Inverse agonist Cimetidine Furan Histamine receptors Imidazole H2 Antagonists Ranitidine GORD Synthesis Development Dyspepsia QSAR Guanidinothiazole Peptic ulcer Bioavailability Famotidine pKa Guanidine Pharmacokinetics Thiazole Formulation Thiourea Metabolism removal Nizatidine Adverse effects Cytochrome P450 Agranulocytosis Nephrotoxicity