Team West Pharmaceutical Sponsor: Tim Miller Adviser: Dr. Harris

Sponsor and Business Leadership in Drug Administration Systems and Components Project Focus: rubber manufacturing for various rubber device components

The Problem Rubber is being tested far too late in the manufacturing process and takes too long Results in excessive material waste, as production continues with wrong formulations

Project Scope Create a rapid, at-line testing method to determine whether a rubber compound was properly mixed and will cure correctly.

Technical Basis Focus on Rubber Production Scorch time, cure rate, performance, viscosity Factors relate to quality of batch

Questions?

Wants/Needs/Constraints Wants –Simple Readout –Cost Effective –Automated Needs –Accuracy of Prediction –Fast Testing –Minimize amount of sample destroyed Constraints –OSHA –FDA

Key Metrics MetricTarget Uncertainty± 2σ Time< 10 min Weight Destroyed< 1/2 lb

Selected Concept At-Line Viscosity Compression Test

Supporting Theory

Preliminary Testing Tests were performed in the CCM to verify testing method using the Instron 5567

Design Determine Viscosity via compression test

Fabrication The device was built from a combination of purchased motor components and machined framework

Calibrations and Programming Labview & GalilTools –Automatically converts and sends appropriate commands to the controller –Allows user to set number of data points –Safeguard to power off motors before critical loads are reached.

Video

Results and Statistical Analysis SampleViscosity (lb-s/in 2 ) A A A A A A Standard Deviation = 2.48×10 -4 (lb-s/in^2) Viscosity factor= (w^4)*8*(1/(h^3))*dh/dt

Meeting Key Metrics

Deliverables Prototype with ability to perform the desired tests Labview program for controlling the tests Method for performing tests and gaining useful data

Path Forward More Calibration Testing Develop a more polished program Build Database of viscosity data The device needs to be a bit more refined, with proper electrical enclosures

Cost Summary Sponsor given range: $5,000 Actual Costs: $4, –Zaber: Stepper Motors-> $ –McMaster Carr and Materials-> $ –Galil: Controller-> $ –Omega: Load Cell->$

Thank You Comments/Questions?