ERGOgenic Aids

Prevalence of Substance Abuse in Sports n Marion Jones first sample + for EPO, 2 nd sample negative; exonerated… …the search for better tests n Justin Gatlin….testosterone n Bonds, McGuire, Palmeiro, Canseco, Arod n Ben Johnson n Cyclists: many, including Floyd Landis n Lyle Alzado

Prevalence of Substance Abuse in Sports n Most studies have focused on alcohol and steroid use: u Alcohol use: % of high school athletes, over 80% of college athletes. u Performance-enhancing drugs: up to 5% of high school and college athletes report using them (higher % among elite athletes, especially in past).

Why Athletes and Exercisers Take Drugs n * Physical reasons include wanting to: u enhance performance u treat injury u look better u control appetite and lose weight

Why Athletes and Exercisers Take Drugs n * Psychological reasons include wanting to: u escape from unpleasant emotions or stress u build confidence or enhance self-esteem u get buzzed/wasted or seek fun/ excitement u “Winning” n Social Reasons include: u emulating athletic heroes u peer pressure

Ergogenic Aids - Definition n Any substance or treatment that either directly improves physiological variables associated with exercise performance or removes subjective restraints that may limit physiologic capacity

Ergogenic Aids n Types u Psychological u Mechanical u Pharmacological u Physiological u Nutritional

Doping Definition (USOC) n “…..the administration of or use by a competing athlete of any substance foreign to the body or of any physiological substance taken in abnormal quantity or taken by an abnormal route of entry into the body, with the sole intention of increasing in an artificial manner his/her performance in competition is regarded as doping..”

Pharmacological Agents n Over the Counter Drugs: u Caffeine, Nicotine, Melatonin….etc; n “Recreational” Drugs: u Alcohol, Marijuana, Cocaine…….etc; n Prescription Drugs: u Anabolic Steroids, Benzodiazepines, Beta- Adrenergic Agents…….etc;

Anabolic Steroids n Testosterone (must be injected or it will be destroyed by digestive enzymes) n Anabolic Androgenic Steroids (AAS) u synthetic drugs designed to mimic the effects of testosterone; taken orally or injected n Human Growth Hormone (anabolic) u used like steroids to increase muscle mass n Beta Adrenergic Agents (Clenbuterol)

Ergogenic Effect and Side Effects of AAS n Increase muscle mass; decrease body fat; improve strength even without training n Side Effects (AAS): u acne; hair loss; male secondary sex characteristics like deepening of the voice; u increased aggression, depression, hostility, suicide attempts, tendency to commit violent acts; u cardiovascular disease (elevated cholesterol, blood pressure) u severe liver damage;tumors (Alzado)….. etc

Effects and Side Effects of Growth Hormone n hormone secreted by pituitary gland; stimulates bone and muscle growth; effects protein, carbohydrate and fat metabolism n currently little data showing ergogenic effects beyond the effect generated by strength training n may lead to diabetes; thickening of soft tissue in face, hands and feet; enlargement of organs such as liver

Effects and Side Effects of Clenbuterol (asthma; illegal in U.S.) n increase lean muscle mass and strength; decrease body fat n less potent than anabolic steroids n side effects: u tachycardia u muscle tension u headaches and dizziness

Physiological Agents n Bicarbonate Loading n Blood Doping n Erythropoietin (EPO) n Altitude Training n Glycerol n Phosphate Loading

Erythropoietin - EPO n Hormone produced by kidneys to stimulate the bone marrow to produce red blood cells n Has same effect as “blood doping” and altitude training (more efficient use of O) n Has same effect as “blood doping” and altitude training (more efficient use of O 2 ) n Illegal n Dangers: increased blood viscosity, clotting potential, increased risk for stroke and heart failure, or pulmonary edema

Nutritional Agents / Supplements n Amino Acid Supplementation n Bee Pollen n Carbohydrate Loading n Carnitine n Coenzyme Q-10 n Creatine Phosphate n Water or Special Beverages

Ergogenic Effect Supported by Research n Legal Supplements / Behaviors u Creatine Phosphate (equivocal) u Caffeine u Altitude training (equivocal)

“There is still no sphere of nutrition in which faddism, misconceptions, ignorance, and quackery are more obvious than in athletics..” (M.H. Williams in Nutrition for Fitness and Sport, 4th ed., 1995)