Schizophrenia: why is it important in South-East London? Robin M Murray Professor of Psychiatric Research Institute of Psychiatry at the Maudsley, Kings.

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Presentation transcript:

Schizophrenia: why is it important in South-East London? Robin M Murray Professor of Psychiatric Research Institute of Psychiatry at the Maudsley, Kings College, London

Self-portrait (11-16 April)

18 May ‘My mind seems to be thought-broadcasting very severely and it is beyond my will to do anything about it. I have summed this up by painting my brain as an enormous mouth’ ‘My mind seems to be thought-broadcasting very severely and it is beyond my will to do anything about it. I have summed this up by painting my brain as an enormous mouth’

South East London Bristol Nottingham All individuals years living in three defined city areas who presented to psychiatric services with their first psychotic episode ÆSOP – epidemiological study of first-episode psychosis in three English Cities London20.1 Nottingham7.7 Bristol7.2 Incidence rate for schizophrenia per 100,000 Kirkbride et al 2006, Arch Gen Psychiatry

Schizophrenia in South-East London Kirkbride, Fearon, Morgan et al., 2007

All PsychosesSchizophrenia Incidence Rate*Rate RatioIncidence Rate*Rate Ratio White British20-7- Black Caribbean Black African Asian (all) *Rates per 100,000 per year; age standardised Fearon, Kirkbride, Morgan et al., 2006 Ethnicity ÆSOP

Substances ever used in Patients with First Episode Psychosis Alcohol (%) Patients (N=596) 68 Controls (N=333) 89 P value0.001 Di Forti et al,

Substances ever used in Patients with First Episode Psychosis Tobacco (%) Patients (N=596) 70.4 Controls (N=333) 47.6 P value<0.00 Di Forti et al,

Substances ever used in Patients with First Episode Psychosis Alcohol (%) Tobacco (%) Stimulants (%) Patients (N=596) 38.1 Controls (N=333) 27.9 P value0.009 Di Forti et al,

Cannabis and Risk of being (OR adjusted for gender, age, ethnicity, Stimulants, level of Ed) OR