 Structures. Source: Introduction to Protein Structure by Branden & Tooze Coiled-coil structure- knob in hole.

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Presentation transcript:

 Structures

Source: Introduction to Protein Structure by Branden & Tooze Coiled-coil structure- knob in hole

Source: Introduction to Protein Structure by Branden & Tooze Coiled-coil structure. Two  helices are interwined and gradually coil around each other. Source: Introduction to Protein Structure by Branden & Tooze

Repetitive pattern of amino acids in a coiled- coil  helix.

Source: Introduction to Protein Structure by Branden & Tooze Packing of hydrophobic side chains between the two  helices in a coiled-coil structure.

Source: Introduction to Protein Structure by Branden & Tooze Salt bridge in a coiled-coil  helix.

Source: Introduction to Protein Structure by Branden & Tooze “Knobs in holes” in a coiled-coil  helix.

Source: Introduction to Protein Structure by Branden & Tooze Dimeric Rop molecule- “knobs in holes” + “ridges in grooves”

Source: Introduction to Protein Structure by Branden & Tooze Globin Domain

Source: Introduction to Protein Structure by Branden & Tooze Ridge on groove

Source: Introduction to Protein Structure by Branden & Tooze ridges & grooves- surface of side chains of  helix

Source: Introduction to Protein Structure by Branden & Tooze Helix packing by “ridges in grooves”

Source: Introduction to Protein Structure by Branden & Tooze Sickle-cell hemoglobin

Source: Introduction to Protein Structure by Branden & Tooze Hemoglobin molecule

Source: Introduction to Protein Structure by Branden & Tooze Sickle-cell hemoglobin molecules polymerization.