Grand Challenge IV Understanding how genomes produce organisms David Raible Board Member, Society for Developmental Biology Professor, University of Washington Sea urchin larvae

Grand Challenge IV Understanding how genomes produce organisms Generation of organismal diversity Heliconius

Grand Challenge IV Understanding how genomes produce organisms Generation of organismal diversity Geospiza

Grand Challenge IV Understanding how genomes produce organisms Environmental influences on growth Arabidopsis

The challenges in developmental biology Generation of cellular diversity Generation of shape: morphogenesis Growth, repair, regeneration Drosophila

The challenges in developmental biology Generation of cellular diversity Generation of shape: morphogenesis Growth, repair, regeneration Carollia

The challenges in developmental biology Generation of cellular diversity Generation of shape: morphogenesis Growth, repair, regeneration Cnemidophorus

Progress at the interface Convergence of genetics and development – Defining components Integration of Cell Biology – Cell shape to tissue architecture Systems biology – the future? – Moving beyond the descriptive

Systematic analysis of development Gene regulatory networks

Systematic analysis of development In toto imaging Kane and Karlstrom, 1995

Systematic analysis of development In toto imaging – xyzgt

Moving forward Instrumentation – ways to measure Centralized databases (GCOB #11) – Access, analyze, manipulate large data sets – Standardization New model organisms – Genomes – Genetics – Lab culture – Transgenics Quantitative training

Moving forward Distribution of effort Centralized resources Distribution of data Recognition