Liu Baochi Shanghai Public Health Clinical Center affiliated to Fudan University Treating patients with liver cirrhosis by BMT

Decompensated liver cirrhosis is difficult to cure liver cirrhosis with AIDS is more difficult to give effective treatment Stem cell treatment bring the hope for the patients of AIDS with decompensated liver cirrhosis. BACKGROUND

7 AIDS patients with decompensated liver cirrhosis and portal ven hypertention, ascites, internal blooding were investigated. Patients

Splenectomy were performed in 7 AIDS patients with liver cirrhosis to alleviate portal vein hypertention and avoid internal blooding. Methods

During the surgical procedure, a catheter was placed in the superior mesenteric vein in preparation for bone marrow transfusion (BMT).

20mL bone marrow was aspirated by puncture of the iliac crest one week after surgery and transfused through the attached catheter into the portal vein. Methods

One or two doses of BMT were performed on each patient at a one month interval.

Results Except diminishment of ascites and recovery of serum albumin levels, total white blood cells and platelet count was also significantly improved. Unexpectedly, one month after BMT, CD4 + T cell count in peripheral blood of all 7 patients began to increase significantly.

age before1month3month12month24month age before1month3month12month24month changes of CD4+ T lymph cell ( /ul) changes of CD8+ T lymph cell ( /ul)

age before1month3month12month24month age before1month3month12month24month ． , changes of albumin （ g/L ） changes of Tbl （ umol/L ）

age before1month3month12month24month ．45．4 5.16, age before1month3month12month24month changes of WBC （ ×10 9 /L ） changes of Plate （ ×10 9 /L ）

age before1month3month12month24month age before1month3month12month24month changes of Hb （ g/L ） changes of PT( 秒 )

liver cirrhosis and highly enlarged spleen with huge amout of ascites before operation four months after operation and BMT. Ascites disappeared and liver enlarged

It may change the standard of liver transplantation Clinical significance of BMT

BMT for the AIDS patient with liver cirrhosis can promote liver function and immune reconstruction. Conclusion