Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry by Kazuhiko Ishihara, and Madoka Takai Interface Volume 6(Suppl 3):S279-S291.

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Presentation transcript:

Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry by Kazuhiko Ishihara, and Madoka Takai Interface Volume 6(Suppl 3):S279-S291 June 6, 2009 ©2009 by The Royal Society

Schematic of a bioinspired interface based on the cell membrane structure. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Molecular assembly for constructing a phosphorylcholine group-rich surface. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Chemical structures of (a) MPC and (b) a typical MPC polymer (PMB). Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

SEM views of surfaces after contact with human whole blood without anticoagulant. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Adsorption of plasma proteins on surfaces. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Relationship between the free water fraction of the polymer and the amount of adsorbed protein on the polymer surface. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Molecular design of the MPC polymer for bioconjugation (PMBN). Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Schematic of the MPEX technique using immobilized oligoDNA primer. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

SEM views of the surface prepared by (a) dip coating and (b) ESD. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Analysis of TSH by ELISA on various surfaces. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

(a) Image of microfluidic devices and (b) ELISA results for the microfluidic devices. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Schematic of functioning of the polymer nanoparticles coated with PMBN. Immobilization of biomolecules on the nanoparticles and embedding of the functional nanoparticles inside the core matrix. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society

Cellular uptake of polymer nanoparticles by specific biomolecules on the surface. Kazuhiko Ishihara, and Madoka Takai J. R. Soc. Interface 2009;6:S279-S291 ©2009 by The Royal Society