VIRUSES CHAPTER 18 Part 1. Characteristics non-living particlesnon-living particles invade living cellsinvade living cells pathogenic - named after the.

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Presentation transcript:

VIRUSES CHAPTER 18 Part 1

Characteristics non-living particlesnon-living particles invade living cellsinvade living cells pathogenic - named after the disease they cause or organ they infectpathogenic - named after the disease they cause or organ they infect smallest of all organismssmallest of all organisms T-4 Virus - infects E. coli

VIRUS - an obligate intracellular parasite INFECTIOUS MONONUCLEOSIS

Origin of Viruses Viruses may have originated from host cellsViruses may have originated from host cells first seen by an electron microscope first seen by an electron microscope Tobacco mosaic virus - first virus discovered Tobacco mosaic virus - first virus discovered Wendell Stanley ( ) first isolated TMV in 1935.

“Living Fluid Infectant” - the virus passed through filters that held bacteria.

Viral Structure Inner core - contains viral DNA or RNA (never both) Capsid - outer coat of protein Envelope - outer layer on larger viruses

hill.com/olcweb/cgi/pluginpop.cgi?it =mov::196::240::/sites/dl/free/ /181977/e21_1int.mov Click on the link above

Various Shapes of Viruses

Viral Replication Lytic Cycle 1. Attachment1. Attachment 2. Injection2. Injection 3. Replication3. Replication 4. Assembly4. Assembly 5. Lysis5. Lysis

LYTICLYTIC LYSOGENICLYSOGENIC

LYSOGENIC CYCLE 1. Attachment 2. Injection 3.Viral DNA integration (provirus) 4. Cell division 5. Replication 6. Assembly 7. Lysis

VIRUSES CHAPTER 18 Part 2

Edward Jenner - discovered a vaccine for smallpox

Smallpox Variola (Major & Minor) First virus to be studied in detail Edward Jenner First vaccine - cowpox virus (vaccinia virus)

Child with smallpox

Last case of smallpox (Ali Maow of Merka, Somalia, contracted smallpox in 1977 at the age of 23. His was the last known case of smallpox in the world.)

Icosahedral Virus (many sides) Wart virus Polio - Naked, small, icosahedral virus

Enveloped Virus INFLUENZA VIRUS

Children with measles (uncommon today)

BACTERIOPHAGE E-Coli Bacteria

Attachment of a phage to the cell wall of E-Coli

Temperate vs. Virulent Viruses

HERPES ZOSTER (“Shingles”)

HERPES VIRUS HERPES

Retroviruses RNA virusesRNA viruses Reverse transcriptase - makes DNA from its RNAReverse transcriptase - makes DNA from its RNA Includes HIV, polio & some cancersIncludes HIV, polio & some cancers HIV

Retrovirus Cycle

HIV / AIDS

Louis Pasteur - discovered a vaccine for rabies

Animal Rabies in U. S. 1999