Topics Covered IT infrastructure Supporting local users Testing Training Informatics Integration Points

IT Infrastructure Currently all applications and web servers that are HIPAA compliant are located on the WUCON (Washington University Clinical Operations Network) behind two firewalls External availability is provided through two load balanced MS Internet Security and Acceleration (ISA) servers to the internet

Monitoring and Availability Currently setting up an HAProxy based Apache cloud in the DMZ to provide our own Named-based Virtual hosting into WUCON. This will allow for unifying end to end responsibility, monitoring, and tracking Not dependent on external (to CBMI) groups for support

Virtualization

Databases CBMI supports many different database for different projects MySQL MS SQL Server DB2 PostgreSQL For OpenSpecimen we currently use Oracle Long term plans to move to PostgreSQL

OpenSpecimen Server Specs Application Server (JBoss) Web Server Operating System Version CentOS 6.5 Local Disk Space 16GB Mounted Disk Space 25GB NA RAM 8GB 1GB Number of Cores 2 1 JBoss Version 5.1 Ant Version 1.7 Java Version 1.6.0.31 Apache Version 2.2

Topics Covered IT infrastructure Supporting local users Testing Training Informatics Integration Points

Release Timeline Alzheimer Disease Renal Research Start Mon 1/2/06 Finish Mon 3/2/15 August 11 August 21 September 1 September 11 September 21 October 1 October 11 October 21 November 1 NCI Funded Development Mon 1/2/06 - Mon 9/30/13 Community Funded Development Thu 1/12/12 - Mon 3/2/15 caTissue Core 1.0 Mon 1/2/06 caTissue Core 1.2 Mon 5/21/07 caTissue Suite 1.0 Thu 4/10/08 caTissue Suite 1.1 Wed 2/18/09 caTissue Suite 1.1.1 Tue 11/10/09 caTissue Suite 1.1.2 Fri 1/29/10 caTissue Suite 1.2 Fri 3/18/11 caTissue Plus 1.0 Thu 11/1/12 caTissue Plus 2.0 Fri 2/1/13 caTissue Plus 3.0 Thu 8/1/13 caTissue Suite 2.0 Mon 9/30/13 caTissue Plus 3.1 Wed 1/1/14 caTissue Plus 3.2 Sun 3/2/14 OpenSpecimen 1.0 Mon 6/2/14 caTissue Plus 3.2.1 Fri 7/11/14 OpenSpecimen 2.0 Mon 12/1/14 OpenSpecimen 3.0 Mon 3/2/15 Alzheimer Disease Renal Research Hepatobiliary – Pancreas Gut Microbiome Pulmonary Users n=100 WashU LTP goes live with Core 1.2 Users n=5

Governance A governance structure is in the process of being formalized Current working form is similar to that of a benevolent dictator that has input from the OpenSpecimen community by way of adopters. Input from Adopters Krishagni Solutions Adopter 1 Adopter 2 Adopter 3 Adopter n Feature requests Adopter funded development New application version New/more clients Support Goals: Increase global adoption Sustained funding model Better product

Migration Mechanism Development Quality Assurance Production Around 6 releases per year Development Quality Assurance Production (high impact / low effort) Application Update Application Update Data 1~2 days old Data 2~4 weeks old Proof of Concept Feature Verification Functional and Regression Testing Integration and Load Testing End User Upgrade Notification Application Support Requirement / Feature Documentation User Documentation and Training Quality Testing Full Integration Testing Data Update Data Update

Challenges Local customizations Enhancements Critical bug fixes BioMS NCI Navigator Data warehouse ClinPortal (CDMS) Enhancements eMPI matching -> integration Scroll bar disappears -> user interface Critical bug fixes JDBC connections not closed properly PPI searches require data entered in exact order

Testing Most heavy on CBMI Limited end user testing Test cases maintained in JIRA Test plans tracked in JIRA Can be >100 test cases depending on release Limited end user testing Push to engage more users More users = more varied workflows

Documentaion Atlassian – Confluence and JIRA

Training Monthly training for new users Verification of HIPAA 2 hour long in-person session Tailored training to users role Online training via NCI e-Learning portal https://cabigtrainingdocs.nci.nih.gov/caTissuePortal/index.html

Topics Covered IT infrastructure Supporting local users Testing Training Informatics Integration Points

ClinPortal Integration caTissue ClinPortal Data management CIDER Data warehouse *Lab results Demographics Medications Diagnosis Procedures Admit/DC Clinical Research at WUSM

ClinPortal-OpenSpecimen Integration Reduce redundancy in participant registry “Simultaneous” registration in both systems pending matching Avoid duplicates in each system Minimize data entry error Navigation across systems Single login Additional method for querying participant data across systems caTissue db ID stored as MRN in ClinPortal Nagarajan Lab, 2012

ClinPortal-OpenSpecimen Integration Participant Clinical Study Registration Collection Protocol Registration ClinPortal caTissue *1 Clinical Study Collection Protocol *2 CS Event CP Event Register simultaneously Visit SCG Form 1 Form 2 … Specimen 1 Specimen 2 … Nagarajan Lab, 2012 19

Join based on Participant Study ID ClinPortal-OpenSpecimen Integration Integrated Query ClinPortal classes Join based on Participant Study ID caTissue classes Nagarajan Lab, 2012

No separate caTissue login action required for navigation ClinPortal-OpenSpecimen Integration No separate caTissue login action required for navigation ClinPortal Event – Activate Encounter Nagarajan Lab, 2012

ClinPortal-OpenSpecimen Integration Nagarajan Lab, 2012

eMPI Integration Electronic Master Patient Index Nagarajan Lab, 2012

WUSTL Biospecimen Navigator Goals Simple UI for searching biospecimen inventory Guest or WashU employee Easily add or subtract from list Submit biospecimen request with minimal data Nice to have End-to-end electronic workflow to support Search Request Distribution Billing

WUSTL Biospecimen Navigator Short term Development – Jan 2015 Deployment – March 2015 Long term Open source Biospecimen information management system agnostic

Acknowledgements The Center for Biomedical Informatics Leslie McIntosh Mark Watson Amy Brink Snehil Gupta Divya Khandekar Melissa McKenna Suhas Khot Atul Kaushal Bijoy George Caerie Houchins Keith Danderand Megan Range

Questions?