LECTURE QUESTIONS. Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations.

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Presentation transcript:

LECTURE QUESTIONS

Hypothesis? Lactose Persistence evolved by strong natural selection in African populations but independently from European populations Methods? They conducted a genotype by phenotype association study in 470 Tanzanians, Kenyans and Sudanese They also tested if the novel association significantly enhance transcription from the LCT promoter in vitro.

Frequency of lactase persistence in East African populations

Are the SNPs associated with lactase persistence in Africans? LP = lactase persistence LIP = lactase intermediate persistence LNP = lactase non-persistence

Are the SNPs associated with lactase persistence in Africans?

Do C-14010, G and G SNPs affect expression in vitro?

How old are these haplotypes?

Are there evidences of Natural Selection?

Yes! Convergent evolution of LP-associated variants