 Maintain internal homeostasis.  Regulate body temperature  Maintain tissue and cellular pH.

 Cardiac fibroblast  Vascular cells  Purkinje cells  Connective tissue cells  Cardiac myocytes

Alcoholic Cardiomyopathy Peripartum Cardiomyopathy

There are several different injury mechanism associated with cardiac toxicants.  Generation of free redicals  Lipid peroxidation  Impaired membrane integrity  Mitochondrial dysfunction  Sarcoplasmic reticulum dysfunction  Altered calcium homeostasis

 Direct and indirect damage to the hematopoietic system may produce hypoxia, hemorrhage, infection and death.  Primary hematotoxicity  Secondary hematotoxicity

Ethanol Sideroblastic anemia Benzene Aplastic anemia Vinyl chloride Acquride prophyria NitratesMethemoglobinemia AntimonyNeutropenia ArsineThrombocytopenia Methyl chloride Hemolytic anemia Warfarin Alteration in blood clotting system Alkylating agents Agranulocytopenia