The Cell Cycle
DNA wraps itself around proteins DNA + protein is called Chromatin As chromatin condenses… DNA has a Double helix shape visible under a light microscope. it becomes This is a naked strand of DNA Visible, compact chromatin makes up a Chromosome
This is another look at how DNA is packaged. Naked DNA Chromatin Supercoils Chromosome
Centrioles Centrosome Centromeres The three C’s that might confuse you.
Interphase
Replicates Centrosomes DNA Chromatin forms supercoils (“S” stage) Cell membrane Cytoplasm The Cell in Interphase (“G 2 ” stage) Nucleolus Nucleus “G 1 ” stage
Mitotic Phase
MITOSIS
The Cell in Early Prophase Chromatin condenses Chromosomes become visible Nucleolus disappears
Nuclear envelope breaks down Centrosomes move apart Spindle fibers form The Cell in Late Prophase
METAPHASE Chromosomes align in middle of the cell Spindle fibers attach to centromeres
METAPHASE Under the microscope, chromosomes may appear flat. In the cell however, chromosomes have a three-dimensional arrangement.
ANAPHASE “Free” spindle fibers lengthen; cell elongates Sister Chromatids separate and move apart Spindle microtubules disintegrate behind chromatids
TELOPHASE Daughter chromosomes reach centrosomes
CYTOKINESIS Cell divides into two identical daughter cells Nuclear membrane reforms TELOPHASE Mitotic spindle disappears Nucleoli reappear
CYTOKINESIS INTERPHASE New daughter cells
Mitosis Animated Click through the next 30 slides to see a rough animation of the cell cycle.
The Cell in Interphase 1
Interphase 2
3
4
5
6
7
Prophase 8
9
10
Prophase 11
Metaphase 12
Metaphase 13
Metaphase 14
Anaphase 15
Anaphase 16
Anaphase 17
Anaphase 18
Telophase 19
Telophase 20
Telophase Cytokinesis 21
Telophase Cytokinesis 22
Telophase Cytokinesis 23
Telophase Cytokinesis 24
Telophase Cytokinesis 25
Daughter Cells 26
Daughter Cells 27
Daughter cells 28
Interphase 29
Interphase 30
MITOTIC EVENTS PRACTICE IDENTIFY THE MITOTIC EVENTS IN THE SLIDES WHICH FOLLOW
What mitotic event is shown? Answer: Anaphase
What mitotic event is shown? Answer: Prophase
What mitotic event is shown? Answer: Telophase
What mitotic event is shown? Answer: Metaphase
Cell Cycle Organizer Cell Cycle Interphase Mitotic Phase Mitosis Cytokinesis Prophase G1G1 S G2G2 Telophase Metaphase Anaphase