Introduction to Bioengineering Presented to Chabot College ENGR10 • Nov06 Ovijit Chaudhuri PhD candidate Department of Bioengineering, University of California Berkeley Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 1

What is Bioengineering? Applying engineering techniques/analysis and technology to biological and medical problems. Some areas (biomedical engineering) are focused on medical applications and using technology for solutions to healthcare problems (traditional). Others are focused on using engineering principles and ideas to understand the way biological systems are constructed. Bioengineering is very interdisciplinary encompassing various fields. Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 2

Prosthetics – Hip replacement Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 3

Medical Imaging MRI, PET, CAT, etc … Cuellar Clinic website Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 4

Biomechanics How stiff does the hip replacement need to be? What kind of loads will it experience? Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 5

Biomaterials Mechanical properties? Materials that are easy to mold? What kind of materials are biocompatible? Wear, tear, corrosion. Immune Response? www.machinedesign.com Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 6

Improving healthcare: Lab on a chip Devices El-Ali, et al., Nature, 2006 Yager, et al., Nature, 2006 Whitesides, Nature, 2006 Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 7

Drug Delivery Microjet injection device Fletcher lab, UC Berkeley Glucose sensor/ delivery device Gough lab, UCSD Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 8

Industry Hip replacement Other prosthetic devices Cardiac stents (Guidant, Johnson and Johnson) Other cardiac devices Drug delivery devices Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 9

Understanding the “engineering” of biological systems - Computational Biology Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 10 Max Delbrueck Center Berlin-Buch

Understanding the “engineering” of biological systems - Synthetic Biology Keasling lab, UC Berkeley Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 11

Understanding the “engineering” of biological systems -Tissue Engineering Engler, et al., Cell, 2006 Kurpinski, et al., Cell, 2006 Nelson, et al., Science, 2006 Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 12

Understanding the “engineering” of biological systems – cell mechanics and motility David Rogers, Vanderbilt U. Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 13

Atomic Force Microscopy Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 14

Our Atomic Force Microscope Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 15

Growing actin networks power cell movement and provide rigidity Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 16 Svitkina, et al.,JCB, 1999

Our studies of actin networks Parekh, et al., Nat. Cell Bio. 2005 Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 17

Questions? Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 18