Role(s) of Interleukin 2

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Role(s) of Interleukin 2 By Shoba Satkuru MSc Biomedical Immunology

Properties of Interleukin 2 Source- Mainly by activated T-cells expressing CD4 surface Ag Structure- 133 amino acids -15.4kDa in weight

Genetic Structure Receptors Contains 4 exons Synthesis regulated at level of transcription Receptors Mediated by membrane receptors 3 types: High Affinity Intermediate Affinity Gamma Subunits

Biological Activities and Functions Stimulates T cell proliferation Stimulates B cell growth/differentiation Generates Lymphokine activated killer cells (LAK cells) Activates macrophages Stimulates T cells to produce other cytokines Stimulates proliferation of oligodendrocytes

Clinical Use & Significance Transgenic animals, knock-out and antisense studies Anti-tumor activity Adoptive Immunotherapy Treatment of cellular immunodeficiency diseases