Non-invasive Fat Reduction Using Focused Ultrasound

What is Fat? Fat cells store excess lipids that are not used as energy. There are Two Major Types of Fat

Stubborn Fat Is Resistant to Diet & Exercise 70% of women say they worry about developing a tummy bulge 1 91% of women say there are things about their body they want to change or reduce2 Most people have tried diet & exercise But they still feel it’s not enough2 1 in 3 women say they have considered more than just dieting and exercise to get rid of their fat2

UltraShape is the first and only FDA cleared procedure that uses focused pulsed ultrasound to: Precisely destroy fat cells protecting surrounding tissue, nerves and muscle For immediate, long-lasting body contouring With no downtime, no discomfort and no side effects What is the UltraShape Procedure? SUBCUTANEOUS FAT UltraShape targets problem areas of stubborn SUBCUTANEOUS FAT

Why Patients Love UltraShape Fast Results Non Surgical No Downtime No Heat No Cold Just Comfort Visible Results Affordable

How UltraShape Gets Rid of Your Stubborn Fat

Ultrasound energy is delivered precisely to stubborn subcutaneous fat 1.5 cm below the skins surface Rapidly changing pressure waves create vapor cavities in fat cells The mechanical stress caused by pressure stresses fat cell membranes causing them to break – releasing lipids (fat) Fat cells are destroyed while skin, nerves, blood vessels and connective tissue are unharmed Effect is purely mechanical, which means no discomfort or heating

Once fat cells are fractured: Freed triglycerides (fat) are safely cleared from the local area They are processed by the body’s natural metabolic pathways and transported to the liver to be used as energy Clinical studies have proven that there are no clinically significant changes in lipid profiles Where Does the Fat Go? Fat Cells Release of Triglycerides 3 Free Fatty Acids Glycerol Transported to the liver and used as energy UltraShape Fat [from the UltraShape procedure] is ultimately processed by the body’s natural physiological and metabolic pathways that handle fat during weight loss.” Spencer A. Brown, PhD, Director of Plastic Surgery Research UT Southwestern Medical Center

The UltraShape procedure has an excellent safety record Over 250,000 patient treatments have been safely performed worldwide Over 600 patients have been the subject of clinical studies on the UltraShape Procedure As with any medical procedure there is always some risk Ask your doctor if you would like additional information on the safety of the UltraShape procedure Is the UltraShape Procedure Safe?

InvestigatorYear Patient Population Avg. Circumference Reduction Results Leal H. 2,3 Monterrey, Mexico cm (1 combo tx) 96% > 1.5 cm circumference reduction 100% patient satisfaction Moreno-Moraga J 1 Madrid, Spain cm 100% measurable and visual improvement Ascher B. 1 Paris, France cm 83% > 1.0 cm circumference reduction Leal H. 2,3 Monterrey, Mexico cm 100% measureable reduction 94% patient satisfaction Ad El D. 2,3 Beilinson Med, Israel cm 90% > 2.0 cm circumference reduction Inglefield C. 2 London, UK cm 93% patient satisfaction de Almeida G. 2 Sao Paulo, Brazil cm 100% measurable reduction 86% patient satisfaction Benchetrit A. 2 Montreal, Canada cm 96% measurable reduction 86% patient satisfaction Ascher B. 1 Paris, France cm (3 tx) 90% reported no pain S.-L. Chang 1,2 Taiwan cm (3 tx) 21.4 and 25% reduction in fat thickness measured by MRI A Selection of Clinical Studies on UltraShape 1 Published in peer-reviewed journal 2 Presented in scientific conference 3 Data on file

What to Expect

The UltraShape procedure is for: Reduction of localized fat deposits Reduction of abdominal circumference Improving body shape and contour A good UltraShape candidate: Has a BMI under 30 Can pinch an inch of soft subcutaneous fat Maintains a healthy lifestyle and diet Has realistic expectations Am I A Candidate? UltraShape is not a treatment for weight loss, obesity, severe skin laxity, cellulite, or a replacement for liposuction

Pacemaker, implanted cardiac defibrillator, or other electromagnetic implanted devices Pregnant, or breast feeding or anticipated pregnancy during the treatment phase Metabolic disorders or are currently taking any medication that could affect fat metabolism Hepatitis or other liver diseases Immune system disease or connective tissue disorders History of poor wound healing, an open wound or rash in the treatment area Keloids, hypertrophic scars, or depressed scars in the treatment area Blood or bleeding disorders UltraShape May Not Be Right For You If:

How long does the UltraShape procedure take? An UltraShape treatment lasts between 45 minutes – 1 hour For best results, we recommend a series of three treatments 2 weeks apart Is the UltraShape procedure painful? The UltraShape procedure is performed during a convenient, “walk-in, walk-out” session performed at an authorized UltraShape treatment center The UltraShape procedure uses pulsed ultrasound, so there is no discomfort caused by cold or heat Some patients report a slight-to-moderate tingling sensation The vast majority of patients report a comfortable treatment experience What Does An UltraShape Treatment Feel Like?

Preparing For Your UltraShape Procedure

Your trained UltraShape treatment provider will : 1.Discuss the treatment with you and answer any questions you have 2.Medically evaluate you to confirm you are a good candidate 3.Check if you have enough fat thickness (over 3 cm) in the treatment area by using a finger pinch test or caliper pinch test. 4.Identify and mark area to be treated 5.Determine treatment pricing based on area to the treated Step I : Treatment Consultation

1.Record measurements of the area to be treated to track circumferential reduction 2.Measurements will be taken and recorded before each treatment 3.A specially designed belt will be placed around your abdomen to isolate the area to be treated Step II: Recording Measurements

1.Markers will be placed around the treatment area for the system to outline the treatment area 2.A special ultrasound gel will be applied on the treatment area 3.Treatment will begin and your entire marked “problem area” will be treated 4.Once treatment is completed, the gel will be wiped from the treatment area 5.Your next appointment will be scheduled in 2 weeks Step III: The UltraShape Treatment

Resume daily routine Avoid weight gain Eat a healthy diet Get routine exercise Reveal your UltraShape! Post-Treatment Instructions Treated fat cells are permanently destroyed. But remember that the key to maintaining your good results is to eat a good diet and have an active, healthy lifestyle.

Patient Results

Results are often visible within days after the 1st treatment* You will see continued reduction up to 3 months after the completion of your 3rd treatment Clinical studies show average reduction of 3.4 cm cm after 3 treatments Maintaining a healthy lifestyle, good diet and exercise program are key to optimizing your results When Will I See Results? Results may vary. Not everyone will experience similar results, each individual will respond differently to the treatment.

Photos courtesy of D. Ad El, MD UltraShape Results After 3 Treatments 4.0 cm reduction Before UltraShape Abdomen

Photos courtesy of D. Ad El, MD UltraShape Results After 3 Treatments 7.9 cm reduction Before UltraShape Abdomen

Photos courtesy of A. Benchetrit, MD UltraShape Results After 3 Treatments 4.7 cm reduction upper abdomen 5.4 cm reduction lower abdomen Before UltraShape Upper/Lower Abdomen

1 Data on file Photos courtesy of M. Lupin, MD UltraShape Results After 2 Treatments 3.1 cm reduction Before UltraShape Abdomen

Photos courtesy of D. Ad El, MD UltraShape Results Abdomen After 2 Treatments 7.7 cm reduction Before UltraShape

Photos courtesy of H. Leal-Silva UltraShape Results After 1 Treatment 6.8 cm reduction Before UltraShape Abdomen

Photos courtesy of C. Inglefield, MD, London, UK UltraShape Results After 3 Treatments 6.5 cm reduction Before UltraShape Lower Abdomen

Photos courtesy of B. Ascher, MD UltraShape Results Abdomen After 3 Treatments 5.0 cm reduction Before UltraShape

Non-invasive Fat Reduction Using Focused Ultrasound PB85591EN-NA