Plenary III: There is No Health Without Mental Health.

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Presentation transcript:

Plenary III: There is No Health Without Mental Health

Disclosures Alexandra Quittner – Investigator-initiated grants: Novartis & Insmed – Consultant to Vertex, AbbVie, and Novartis – Research support from CF Foundation, EU, Australia NHMRC Stuart Elborn – Clinical trials and consultancy with Novartis, Vertex, Celtaxsys, Corbus – Research support from MRC, EC Framework 7, CF Trust UK – European CF Society Beth Smith – Grant support from the Cystic Fibrosis Foundation and the New York State Office of Mental Health

There Is No Health Without Mental Health Alexandra L. Quittner, PhD University of Miami Miami FL USA

Premises of Our Plenary 1 st Premise: Our well being includes both physical and mental health Treating the Whole Person

Premises of Our Plenary 2 nd Premise: We have reliable, valid tools to measure these symptoms – Just like getting your blood pressure checked 3 rd Premise : If you have a chronic illness, or if you care for a child with a chronic illness – Feelings of depression and anxiety are normal responses to a challenging situation – Importantly, these feelings affect our behavior

Impacts of Cystic Fibrosis Mental Health (Depression) Adherence

Impacts of Cystic Fibrosis  Clinic Attendance  Exacerbations  Lung Function  BMI  Quality of Life Mental Health (Depression)

Chronic Conditions & Mental Health Individuals with chronic conditions are at greater risk for symptoms of depression and anxiety 1,2 – Parent caregivers are also at elevated risk 3 In CF, single center studies have also found elevated rates of depression and anxiety 4-6 So the international community decided to assess the prevalence of these symptoms … In our patients & parents in 9 countries 1-Pinquart & Shen. J Pediatr Psychol. 2011;36(4): Moussavi et al. Lancet. 2007;370(9590): Barker & Quittner, J Pediatr 2015 in press 4- Yohannes et al. Respir Care. 2012; 57(4): Moussavi et al. Lancet. 2007; 370(9590): Snell et al. Pediatr Pulmonol. 2014;49(12):

8 EU Countries 45 US Care Centers Funded by CF Foundations in Several Countries Quittner et al. Thorax. 2014;69(12):

TIDES Methods Two brief screening measures for depression and anxiety were administered in clinic by a CF Team member Background/medical information form completed – verified by chart review 6088 patients and 4102 caregivers screened! Quittner et al. Thorax. 2014;69(12):

TIDES: Prevalence of Depression above the Clinical Cut-Off Score Quittner et al. Thorax. 2014;69(12): to 3 Times Community Prevalence

TIDES: Prevalence of Anxiety above the Clinical Cut-Off Score Quittner et al. Thorax. 2014;69(12): to 3 Times Community Prevalence

Concordance of Adolescent-Parent Depression and Anxiety For the 1130 parent-adolescent pairs: – Adolescents were 4.80 times more likely to be above the cut-off for depression if parent was elevated – Adolescents were 3.53 times more likely to be above the cut-off for anxiety if a parent was elevated This highlights the importance of screening parents Quittner et al. Thorax. 2014;69(12):

Conclusions There is a high prevalence of depression and anxiety in people with CF and caregivers – 2-3 X the prevalence in the general population – Effects on adherence, health care costs, quality of life and health outcomes Parents also reported a high prevalence of depression and anxiety – the concordance between parent-teen symptoms suggest that we need to screen both patients and caregivers Thank You

International Committee on Mental Health in Cystic Fibrosis: CFF and ECFS Consensus Statements for Screening and Treating Depression and Anxiety J. Stuart Elborn, MD Queen’s University, Belfast UK

A Collaborative Effort The International Committee on Mental Health in CF Wide range of experts, people with CF and parents involved Two meetings in USA and Europe Regular steering group meetings Much work in between by the subgroups

Working Groups: Assessment and Treatment of Depression and Anxiety Screening Psychological Intervention Pharmacologic Treatments Future Research Draft Consensus Statements Literature Searches Review/Approve Topic-Specific Questions PICO format: (Population, Intervention, Comparison, Outcome)

Review and Comment: Clinicians, People with CF, & Parents Draft Manuscript Consensus Process ≥80% agreement <80% agreement Draft Consensus Statements Committee Review/Voting Accepted Statements Agreed manuscript in Press (Thorax Sept 2015)

Rescreen at Next Clinic Visit Administration of PHQ-9 & GAD-7 Clinical Concerns Depression/Anxiety Annual Screening Depression/Anxiety Symptoms Supportive Interventions Clinical Assessment ImpairmentPatient PreferencesRisk Evidence-Based Psychological and/or Psychopharmacological Intervention Normal Range Elevated Range Moderate Severe Mild Range Flexible, Step-Care Model

Pharmacological Intervention Appropriate 1 st line SSRI* antidepressants – Citalopram – Escitalopram – Sertraline – Fluoxetine Close monitoring of therapeutic effects, adverse effects, drug-drug interactions, and medical comorbidities is recommended *selective serotonin reuptake inhibitors

Caregiver Screening and Assessment Administration of PHQ-9 & GAD-7 Annual Screening Evidence-Based Psychological Intervention, including CBT or IPT, or referral to mental health specialist Assess Child (Ages 7-11) Clinical Concerns About Child Consultation Refer Caregiver for Preventative or Supportive Intervention Mild Range Elevated Range Moderate Severe Normal Range Referral as appropriate

Summary People with CF and their families are at high risk for depression and anxiety leading to both poor quality of life and poor health outcomes An international working group has created consensus mental health screening and treatment guidelines for people with CF and their caregivers Detailed processes for screening and, if necessary, intervention have been identified

Mental Health Care Delivery Capabilities Survey distributed by CFF and ECFS* – 4,000 CF Health Professionals in EU and North America – 1,454 responses (36%) * Abbott et al. J Cyst Fibros 2015;14(4):533-9 Team Member with Primary Responsibility of Mental Health? NO 23% Personal Experience with Mental Health Screening? NO 79% Ability to Refer to Institutional Mental Health Clinicians? NO ? 18% 14%