Features and Benefits of Snap Combo Plus

2 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 Antigen and Antibodies -The Battle Begins The body has an army of soldiers consisting of white cells and antibodies waiting for the invasion by the enemy (antigens). The antigen stimulates production of the antibody. When the antigen and antibody come into contact, the antibody locks on to the antigen. This process is called “binding.” The result is the antigen antibody immune complex.

3 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 Why should a vet use IDEXX products rather than competition? IDEXX Snap Combo is the only test that can identify the proteins P15, P24, and GP40. All of these antigen proteins are indicators of the FIV Virus. IDEXX can identify more cases of FIV than any other test on the market because the other tests only identify the protein GP40. Only in-clinic test that uses Elisa Technology Conjugate – enhances ur - identifies weak positives Bi-directional Flow – twice the time allows for greater sensitivity Wash Solution – eliminates non-specific binding Amplification of results – identifies weak positives

4 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 Enzyme-Linked Immuno-Sorbent Assay

5 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 SNAP Technology Only ELISA technology rapid test in the market Bi-directional flow of samples and wash allows for efficient washing of the samples which removes any background interference. This makes the test easy to read even when the sample is damaged. True blue color means the test spots amplify blue, not red (the color of blood) like the competitors (in US) Highest sensitivity due to the enzyme amplifier that is present in the conjugate Highest specificity due to wash step Patented technology

6 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 What is Sensitivity? Sensitivity = # of detected positives / # of known positives = a true positive. Example: 100 known positive parvo dogs. If Snap test detects 95 positive dogs from the original 100 then Snap has 95% sensitivity. 5 false negatives. We missed 5 samples that were true positives.

7 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 What is Specificity? Specificity = # of detected negatives / # of known negatives = a true negative. If Snap called a true negative a positive = false positive. For example, if 100 dogs are truly negative for the Parvo Virus but our test says that 5 are positive than our test is 95% specific. It falsely identified 5 dogs as positive even though they do not have Parvo.

8 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 How is Accuracy Determined? Accuracy is presented in a percentage form based upon the sensitivity and specificity. The higher the sensitivity and specificity, the more accurate the assay. Accuracy = sensitivity + specificity / 2. Example: 95(SENS) + 100(SPEC) divided by 2 = 97.5%.

9 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15

10 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15

11 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 - Amplification of signal via enzyme reactions (ELISA) (increased sensitivity) - Bi-lateral flow (SNAP) - hits reactive spot twice, increasing signal - includes wash step for clear background (increased specificity) -Simultaneous detection of: FIV with FeLV Why Snap®?

12 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 Signal Amplification The Snap® device uses an enzyme to AMPLIFY the signal from one antigen or antibody molecule to 100s of color molecules. Think of one blue bubble bursting onto 100 clear bubbles turning ALL the bubbles blue. This technology allows are tests to achieve the HIGHEST sensitivity

13 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 The Wash Step The Snap® device includes a wash step that removes non-specific binding. Think of the wash as a cleaner that clears away any of the blue that sticks to the wrong types of bubbles. This allows us to achieve the Highest specificity.

14 © 2005 IDEXX LABORATORIES, INC. | Proprietary and Confidential | 22-Nov-15 SNAP Technology Only ELISA technology rapid test in the market Bilateral flow of samples and wash allows for efficient washing of the samples which removes any background “noise”. This makes the test easy to read even with bad samples. True blue color means the test spots amplify blue, not red (the color of blood) like the competitors Highest sensitivity due to the enzyme amplifier that is present in the conjugate Highest specificity due to wash step Patented technology Most used test in the Veterinary industry