Photograph of a Zmpste24−/− mouse, illustrating a characteristic dragging of the hind limb. Bergo M O et al. PNAS 2002;99:13049-13054 ©2002 by National.

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Presentation transcript:

Photograph of a Zmpste24−/− mouse, illustrating a characteristic dragging of the hind limb. Bergo M O et al. PNAS 2002;99: ©2002 by National Academy of Sciences

Growth rates and grip strength in mice. Fong L G et al. PNAS 2004;101: ©2004 by National Academy of Sciences

Western blots of extracts from wild-type, Zmpste24–/–, and Zmpste24–/–Lmna+/– MEFs with a carboxyl (C)-terminal prelamin A antibody and an amino (N)-terminal lamin A/C antibody. Fong L G et al. PNAS 2004;101: ©2004 by National Academy of Sciences

Nature 423, (15 May 2003) | doi: /nature01631; Received 10 February 2003; Accepted 8 April 2003