Promoting Maturity Dec 2 Preview Generally speaking KC, Here I Come Traffick Jam
This promotes a myeloid progenitor to become a RBC
What is erythropoietin?
This promotes a myeloid progenitor to become a megakaryoblast.
What is thrombopoietin?
This interleukin promotes a myeloid progenitor to become a eosinophil.
What is IL5?
This cytokine is essential for mast cell development.
What is stem cell factor (or c-Kit ligand)?
This TNF family cytokine is required for naïve B cell survival.
What is BAFF (or B cell activating factor)?
It is the part of the immune system that has no memory.
What is the innate immune system?
They are cells of the innate immune system that are sometimes called polymorphonuclear cells.
What are neutrophils?
These small cationic peptides are produced by epithelial cells and are directly toxic to microbes.
What are defensins (or cathelicidins)?
These two cytokines are known to downregulate inflammation and induce tolerance.
What are IL-10 and TGF-β?
They are the largest group of NK inhibitory receptors and bind MHC class I molecules.
What are KIRs?
This secondary lymphoid organ is the primary site of immune response to blood borne infections.
What is the spleen?
This cell transports macromolecules from the intestinal lumen into the subepithelial tissue.
What is an M cell?
Along with CD62L, this cell marker is found on naïve T cells and is used to diagnose complete DiGeorge syndrome.
What is CD45RA?
Lymphocyte egress from lymph nodes is dependent on this concentration gradient.
What is S1P/S1P1R?
This interleukin recruits neutrophils, is secreted by macrophages in response to TLR signaling and is a mediator of psoriasis.
What is IL8?
This city hosted the most NCAA men’s basketball division I championships in the 20 th century
What is Kansas City?
Kansas City has more fountains than any other city in the world except this city?
What is Rome?
The shopping area in Kansas City known as “the plaza” was modeled after this city in Spain.
What is Seville?
The star of “Steamboat Willie” was first drawn by this cartoonist while he was in an office on Hospital Hill.
Who is Walt Disney?
Before receiving both a Pulitzer Prize and a Nobel Prize in Literature, this man wrote for the Kansas City Star.
Who is Ernest Hemingway?
Both of these types of selectins are found on the endothelium.
What are E and P selectins?
L-selectins are highly expressed on naïve T cells mediating their binding to these on HEVs.
What is peripheral node addressin (PNAd)?
MadCAM-1 binds to this integrin on lymphocytes during gut homing.
What is α4β7?
This chemokine receptor is found on naïve T cells and helps them travel to the T cell zone of lymph nodes.
What is CCR7?
This chemokine receptor is found on naïve B cells and helps them travel to lymph node follicles.
What is CXCR5?