بسم الله الرحمن الرحيم

Leukocytes Leukopenia Leukocytosis

Leukopenia (Agranulocytosis) Myeloid stem cell suppression Ineffective granulopoisis Heriditary disorders, kostmann syn. Immune destruction Spleenic sequestration Peripheral destruction

Leukocytosis

Normal Lymph node

Lymphadenitis Acute nonspecific lym. Chronic non specific lym. –Follicular hyperplasia –Sinus histiocytosis –Paracortical hyperplasis

Neoplastic proliferation of leukocytes –Lymphomas –Leukemias –Plasmacell dyskerasia –Langerhans cell histiocytosis

Lymphoproliferative disorders Lymphomas Leukemias Plasma cell dyscrasia Lymphomas Leukemias Plasma cell dyscrasia

Myeloid Neoplasms Acute Leukemias Chronic Leukemias Myelodysplastic disorders Myeloproliferative disorders

Lymphomas Hodgkins lymphoma (HD) Non Hodgkins lymphoma (NHL)

Hodgkin's Lymphoma

Non Hodgkin's lymphoma

Leukemia Classification Acute Aml, ALL Chronic CML, CLL Acute Aml, ALL Chronic CML, CLL

Myeloblast Lymphoblast ChromatinFineClamp Nucleoli 3 – Granules Variable Non PA - + Tdt %5 % 95 Sudan Black +- Mpo + -

A.M.L

A.L.L

Myelo dysplastic syndromes Refractory anemia R.A with ring sideroblast R.A with excess blast Chronic myelomonocytic leukemia RAED in trans Formation CMML in trans Formation

Chronic myeloproliferative disorders CML P.V MMM disease E.T

Chronic lymphoproliferative disorders CLL PLL NHL HCL

Plasma Cell neoplasms Multiple myeloma Solitary plasmacytoma Waldenstorm macroglobulinemia Heavy chain diseases Primary Amiloidosis Monoclonal Gamma pathy U.S

Histiocytoses Langerhans H / HistiocytosisX Eosinophilic granuloma Acute disseminated H. ((Letterer – Siwe synd)) Hand schuller chrisrian disease

Morphologic aspects HLA – DR CDa Birbeck (HX) granules