Single molecule manipulation: magnetic tweezers INESC-MN Magnets (NdFeB) Magnets (NdFeB) Resolution 5 nm [ ] Seidel et al, Nature Structural & Molecular.

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Presentation transcript:

Single molecule manipulation: magnetic tweezers INESC-MN Magnets (NdFeB) Magnets (NdFeB) Resolution 5 nm [ ] Seidel et al, Nature Structural & Molecular Biology 11, (2004) 52nd MMM Conference – Tampa FL November 2007 FA-05 3/38 EcoR124I

INESC-MN 53rd MMM Conference – Austin TX November 2008 CG-05 Micro Fabricated Structures (Without Fluidic Chamber) Spin Valves & Magnetic Tunnel Junctions 6

Magnetic Tweezer, DNA manipulation, DNA translocation I AC I DC V +, I + V -, I - 10  m M.R. ATP FP6 BioMolSwitch

INESC-MN Optical  Scope – Vertical Switch 52nd MMM Conference – Tampa FL November 2007 FA-05 28/38 45 mA I MT 0 mA

INESC-MN 53rd MMM Conference – Austin TX November 2008 CG-05 7 Micro Fabricated Structures (Without Fluidic Chamber) Spin Valves & Magnetic Tunnel Junctions

INESC-MN 53rd MMM Conference – Austin TX November 2008 CG-05 Bead Detection Intermixing frequency 16