Bordbar, Feist, Usaite-Black, Woodcock, Palsson, Famili BMC Systems Biology 2011.

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Bordbar, Feist, Usaite-Black, Woodcock, Palsson, Famili BMC Systems Biology 2011

Obese vs. Diabetic Obese Gene expression samples from gastric bypass patients in fasting state. Objective: AM triacylGlycerol + MM protein  HM glucose Unique reactions: Gene expression: 27 obese, 40 diabetic Multi-tissue model: 29 obese, 94 diabetic Expression FP: 39 of 67 Differences mainly in AM

Obese vs. Diabetic Obese Diabetic AM: [deminished insulin response]  carnitine shuttle and FA oxidation  Elevated free FA, lactate  HM gluconeogenesis  hyperglycemia Diabetic catalase is inactive  causes oxidative damage to tissues Diabetic cysteine deoxygenase is inactive (breaks down excess cysteine to pyruvate and taurine)