RAINBOW A comparative study of surgery for inflammatory bowel disease Ruth Blanco Colino, Tom Drake, Laura Gavagna, Camilla Kjeldsen, Samuel Lee

Why?  Inflammatory Bowel Disease is common  Outcomes  Young patients  Non-cancer research priority

Strengths  Defined, relatively low volume, population allows focussed data collection  Common Condition  Easily understood by students  Wide scope for future studies and involving students in European trials

Aims  To conduct a multicentre, high-quality prospective cohort study of surgical management for IBD across Europe  To determine risk-adjusted 30-day and 12-month outcomes of surgery for IBD

RAINBOW Patient Care Hypothesis Generation Clinical Evidence Education Trials Data Access Students into trials Incorporating students and early career doctors into trials Collaboration as a resource

Population  All patients undergoing resection for ulcerative colitis or Crohn’s disease

Primary Outcome 30 days + 12 months 30 days + 12 months Follow-up… Primary Outcome  Overall complication rate  Adjusted for variables prior to index event of operation

Secondary Outcomes 30 days + 12 months 30 days + 12 months Follow-up… Secondary Outcomes  Specific Complications: -Venous Thromboembolism -Infectious complications -Anastomotic leakage -Stoma complications  Pathological quality of resection  Disease Recurrence  Length of stay  Reoperation  Readmission

IBD disease activity Role of perioperative biologic therapy Prognostic Blood Tests Faecal Calprotectin Perioperative nutrition Surgical technique & emergency Proposed Outputs

Scope for ‘plug-in’ studies  Quality of Life Outcomes -IBDQ-9 -EQ-5D  Patient Reported Outcome Measures  Psychological repercussions -Body image -Depression

Summary FUTU RE TRIA LS EASY TO CONTR OL RESEARC H PRIORIT Y LOTS OF PATIEN TS

Thank you Any questions? ?