Inhibition of pathogenic SHIV replication in macaques treated with antisense DNA of interleukin-4 by Navneet Kaur Dhillon, Yongjun Sui, Raghava Potula,

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Inhibition of pathogenic SHIV replication in macaques treated with antisense DNA of interleukin-4 by Navneet Kaur Dhillon, Yongjun Sui, Raghava Potula, Sukhbir Dhillon, Istvan Adany, Zhuang Li, Francois Villinger, David Pinson, Opendra Narayan, and Shilpa Buch Blood Volume 105(8): April 15, 2005 ©2005 by American Society of Hematology

Replication of SHIVKU-2 in response to rmIL-4 and AS IL-4 in macaque PBMCs and monocyte- derived macrophages. Navneet Kaur Dhillon et al. Blood 2005;105: ©2005 by American Society of Hematology

Viral protein staining in SHIVKU-2–infected rhesus MDMs after treatment with IL-4 protein and AS IL-4 ODN. MDM cultures were grown on chamber slides, inoculated with SHIVKU-2 for 4 hours at 37°C, washed, and untreated (A) or then treated with either rmIL-4... Navneet Kaur Dhillon et al. Blood 2005;105: ©2005 by American Society of Hematology

Levels of IL-4 mRNA in SHIVKU-2–infected CD4+ T cells treated with rmIL-4 or AS IL-4 as seen by RT-PCR and quantitative real-time RT-PCR. Navneet Kaur Dhillon et al. Blood 2005;105: ©2005 by American Society of Hematology

SHIV89.6P replication in macrophages in the presence of sense or AS IL-4 plasmid. Navneet Kaur Dhillon et al. Blood 2005;105: ©2005 by American Society of Hematology

Colocalization of GFP (green) and in vivo MegaFectin complexes (red) in spleen, lungs, and liver of a macaque. Navneet Kaur Dhillon et al. Blood 2005;105: ©2005 by American Society of Hematology

Plasma viral load and CD4+ T cell counts in the peripheral blood of ASIL-4 treated and untreated macaques. Navneet Kaur Dhillon et al. Blood 2005;105: ©2005 by American Society of Hematology

Viral RNA load in AS IL-4 DNA treated and untreated SHIV-infected macaques as seen by real- time RT-PCR and immunohistochemistry. Navneet Kaur Dhillon et al. Blood 2005;105: ©2005 by American Society of Hematology