Cellular Transport and Tonicity

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Presentation transcript:

Cellular Transport and Tonicity Biology 2121

Selective Permeability of the Plasma Membrane Which substances can move freely through the phospholipid bilayer? Water, gases (oxygen, carbon dioxide); fats Small- polar; nonpolar molecules Which substances are blocked? Glucose; ions Larger substances (polar) Processes Passive (no ATP) High to lower concentration gradients Driving Force? KE of the substances Active (requires ATP) Low to higher concentration gradients

Passive Processes 1. Diffusion vs. Osmosis 2. Simple Diffusion Gases; nonpolar; lipid soluble substances (fat-soluble vitamins) 3. Facilitated Diffusion Sugars (glucose; amino acids; ions) Integral or Transmembrane proteins Channel or carrier proteins 4. Osmosis Movement of water dependent on solute concentration (extracellular/intracellular)

Tonicity Measure of the ability of a solution to cause a change in cell shape or tone caused by osmotic flow of water Why does osmosis occur? Water concentration differences Solute concentration affects water concentration Dependent on the number (concentration) Osmolarity Permeability of solute molecules Permeable to all solute molecules – equilibrium If membrane is impermeable (see U-tube)

Water Movement and Solute Concentration

Tonicity – Conditions Isotonic Hypertonic Hypotonic Cells have same concentrations of non-penetrating solutes as found in cells Our cellular fluids and IV’s Hypertonic Solutions have higher concentration of non-penetrating solutes Salty or high saline conditions Hypotonic Solutions containing a lower concentration of non-penetrating solutes “dilute”

Active Transport Driving Force? ATP Sodium-Potassium Pump Solute “pumps” (ions- K+, Na+, etc.) Sodium-Potassium Pump “primary active transport” Neurons, cardiac and skeletal tissue Vesicular Transport Fluids contain large particles and macromolecules Vesicles

Vesicular Transport Exocytosis Endocytosis “ejects” substances from cells Hormone and mucous secretion Endocytosis Substance moves into cell and vesicle formed transcytosis, vesicular trafficking Phagocytosis Pinocytosis