Project Clot: Clot Detection Device for Stroke Prevention Team Atriumph: Erica Kim, Angela Li, Sam Vallagomesa, Michael Williams-Hart
Background & Motivation Agenda Market & Customer Analysis Design Specifications Moving Forward
Atrial Fibrillation Most common type of arrhythmia Affects 3.2 million people in the U.S.
Atrial Fibrillation fatigue difficulty breathing dizziness
Embolic Stroke in AF Patients Accounts for >15% of all strokes in the U.S No effective method for stroke prevention in AF patients Detection treatment
Left Atrial Appendage (LAA)
Embolic Stroke in AF Patients AF Episode Reduced LAA function Blood stasis Clot Formation Regain LAA function Pump out clot Embolic stroke Clot Formation
Blood stasis Clot Formation Regain LAA function Pump out clot Embolic stroke Design and test a clot detection & monitoring device to prevent embolic stroke for patients with atrial fibrillation Project Clot Team Atriumph
Transesophageal Echocardiogram (TEE) Description Uses high frequency sound waves to produce images of the posterior side of the heart
Transesophageal Echocardiogram (TEE) Advantages 100% sensitivity 99% specificity Current standard of care
Transesophageal Echocardiogram (TEE) Disadvantages Moderately invasive Expensive Requires skilled technician or cardiologist
Description Cardiac Computed Tomography (CT) Uses x-ray to produce cross-sectional images of a scanned object
Cardiac Computed Tomography (CT) Advantages 96% sensitivity 92% specificity Non-invasive
Cardiac Computed Tomography (CT) Disadvantages Uses radiation Expensive Requires clinical setting
Clot Detection Devices are Novel TEE & CT used only before ablation procedure Specifically used for clot detection Permanent implant continuously monitors patient Notifies patient YES or NO to clot formation outside clinical setting Are not monitoring techniques Requires clinical setting
Clot Detection Devices are Novel TEE & CT used only before ablation procedure Specifically used for clot detection Permanent implant continuously monitors patient Notifies patient YES or NO to clot formation outside clinical setting Are not monitoring techniques Requires clinical setting
Clot Detection Devices are Novel TEE & CT used only before ablation procedure Specifically used for clot detection Permanent implant continuously monitors patient Notifies patient YES or NO to clot formation outside clinical setting Are not monitoring techniques Requires clinical setting
Market Analysis Estimated Market SizeWillingness to Pay Predicted Market Share 119,250 patients/year approx. $2,500 15% $45 million/year Estimated Financial Opportunity
Market Analysis Estimated Market SizeWillingness to Pay Predicted Market Share 119,250 patients/year approx. $2,500 15% $45 million/year Estimated Financial Opportunity
Market Analysis Estimated Market SizeWillingness to Pay Predicted Market Share 119,250 patients/year approx. $2,500 15% $45 million/year Estimated Financial Opportunity
Market Analysis Estimated Market SizeWillingness to Pay Predicted Market Share 119,250 patients/year approx. $2,500 15% $45 million/year Estimated Financial Opportunity
Market Analysis Estimated Market SizeWillingness to Pay Predicted Market Share 119,250 patients/year approx. $2,500 15% $45 million/year Estimated Financial Opportunity
Clinician Patient User COMPANY LOGO Customer Needs Analysis
COMPANY LOGO Customer Needs Analysis Accuracy Safety Ease of Use Maintenance Cost
COMPANY LOGO Translating Needs to Specs Accuracy Safety Ease of Use Maintenance Cost
COMPANY LOGO 90-95% Sensitivity & Specificity Safety Ease of Use Maintenance Cost Translating Needs to Specs
COMPANY LOGO Sensitivity & Specificity Safety Ease of Use Maintenance Cost Translating Needs to Specs
COMPANY LOGO Sensitivity & Specificity Biocompatible Ease of Use Maintenance Cost Translating Needs to Specs
COMPANY LOGO Sensitivity & Specificity Biocompatible Ease of Use Maintenance Cost Translating Needs to Specs
COMPANY LOGO Sensitivity & Specificity Biocompatible Maintenance Cost User Friendly Interface Translating Needs to Specs
COMPANY LOGO Sensitivity & Specificity Biocompatible Maintenance Cost User Friendly Interface Translating Needs to Specs
COMPANY LOGO Sensitivity & Specificity Biocompatible ? Cost User Friendly Interface Translating Needs to Specs
COMPANY LOGO Sensitivity & Specificity Biocompatible ? Cost User Friendly Interface Translating Needs to Specs
COMPANY LOGO Design Specifications Sensitivity & Specificity Biocompatible User Friendly Interface ? Competitive Pricing
Mission Statement Blood stasis Clot Formation Regain LAA function Pump out clot Embolic stroke Design an intracardiac device that detects clots in the LAA accurate safe user friendly
Moving Forward mid Oct end of Oct early Nov Mar Commit to a modality of sensing technology Finalize our first design (iterative process) Create first working prototype (iterative process) Complete and file a provisional patent Complete final design and prototype end of Sept. 2015
Project Clot Team Atriumph Regain LAA function