Modeling and Synthetic Biology DAY THREE: PART ONE.

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Presentation transcript:

Modeling and Synthetic Biology DAY THREE: PART ONE

What is a model?

Model -Concrete -Descriptive -Abstract

Why build a model

Why Model? -Reveals relationships which were not previously apparent -Not possible to make a physical measurement -Large volume of data -Infeasible experiments -save cost/time

Criticism

Model -‘Of course your model predicted what you wanted to - you built it’ - ‘I could have figured it out without your model just by doing a simple experiment’

Types of models 1. Rule-based models 2. Mass action kinetics 3. Stoichiometric matrix

In class excercise

Model : Steps for Building 1.Graphical depiction 2.System deﬁnition (boundaries & assumptions) & data collection 3. Mathematical expressions 4. System analysis 5. Model curation - ‘I could have figured it out without your model just by doing a simple experiment’