A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, OX11 0QX, UK.

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Presentation transcript:

A simple introduction to Science at ISIS Robert McGreevy ISIS Facility, CCLRC Rutherford Appleton Laboratory, Chilton, Didcot, OX11 0QX, UK.

RAL December 5 th 2005

To see small things – you need a big thing …

RAL December 5 th 2005 ’Neutrons (and muons) tell you where atoms are and what atoms do’ What can neutrons and muons do?

RAL December 5 th 2005 DiamondGraphiteFullerene

RAL December 5 th 2005 Neutron Diffraction

RAL December 5 th 2005

Inelastic Neutron Scattering

RAL December 5 th 2005 Time of flight method Particle Momentum – k (velocity) Energy - E WaveWavelength – λ (length scale) 1000 m/s 20 m μsμs 20 ms m

RAL December 5 th 2005

unique Neutrons see the world in a unique way Length and time scales – m – s From hydrogen … … to hydrogenase

RAL December 5 th 2005 unique Neutrons see the world in a unique way Length and time scales – m – s From hydrogen … … to hydrogenase

RAL December 5 th 2005 unique Neutrons see the world in a unique way

RAL December 5 th 2005 unique Neutrons see the world in a unique way Penetration Large samples, buried interfaces, non-destructive

RAL December 5 th 2005 unique Neutrons see the world in a unique way Magnetism The neutron has a magnetic moment but no charge

RAL December 5 th 2005 unique Neutrons see the world in a unique way + + = Sensistivity and selectivity Isotopic substitution/contrast variation

RAL December 5 th 2005 unique Neutrons see the world in a unique way a(4K) = (2) Å 18 th order spherical harmonic c 18,1 = ; c 18,2 = Precision Weak interaction, simple interaction

RAL December 5 th 2005

Crystallography Powder diffraction HRPD POLARIS GEM HiPr (ROTAX) WISH (TS2) Single crystal diffraction SXD Engineering diffraction ENGIN-X

RAL December 5 th 2005 Single crystal diffraction - SXD

RAL December 5 th 2005 Anticancer drug studied on SXD in 2005 C. K. Broder et al.

RAL December 5 th 2005 Anticancer drug studied on SXD in 2005 C. K. Broder et al.