Utilizing NeSSI™ for Analytical Applications Dave Veltkamp, CPAC New Sampling/Sensor Initiative (NeSSI™)

Overview of Talk Describe the features of NeSSI™ most likely to impact lab applications Discuss how NeSSI™ can facilitate laboratory applications and how current development fits lab needs Outline some outside proposals recently written to help fund NeSSI™ development & demonstration Mention some web-based resources at CPAC

What does NeSSI™ Provide Simple “Lego-like” assembly Easy to re-configure No special tools or skills required Standardized flow components “Mix-and-match” compatibility between vendors Growing list of components Standardized electrical and communication (soon) “Plug-and-play” integration of multiple devices Simplified interface for programmatic I/O and control Advanced analytics and measurement environment Mini or Micro-analyzers Integrated analysis or “smart” systems Expose students to “Industrial” techniques & needs

NeSSI™: Enabler for MicroAnalytical (the “rail” concept) Standard Mechanical Interface “Rail” Standard Electrical (Digital) Interface “Rail” Anyone’s Sensor Anyone’s Actuator SAM* Standard “hockey-puck PC” P V *Sensor/Actuator Manager Standard “connectivity ”

How Does NeSSI™ Fit in the Lab Instrument/Sensor Interfaces Design standards make development simpler Reduced toolset to be mastered Reduced toolset to be mastered Reduced sample variability to account for Reduced sample variability to account for Calibration/validation built-in Consistent physical environment for measurement Consistent physical environment for measurement Stream switching and/or mixing allow generation of standards to match analytical requirements Stream switching and/or mixing allow generation of standards to match analytical requirements Reaction monitoring Microreactors and continuous flow reactors Batch reactors (with fast loop) Sample Preparation Gas handling (mixing, generation, delivery) Liquid handling (mixing, dilution, conditioning, etc.)

Special Lab NeSSI™ Requirements Flowing streams Need to move liquid and gas streams through NeSSI™ Most laboratory analysis involves discrete samples rather than sample streams Analytical characterization of flow in NeSSI™ needed Heating and Cooling Laboratory applications need both May require more rapid thermal response Integration with other lab apparatus Serial communication most common Integration with lab software systems Low cost Competing with other solutions that don’t carry some of NeSSI’s more exotic features

Recent proposals featuring NeSSI™ NSF Instrumentation for Materials Research (IMR) Involves NeSSI™ and Microreactors to elucidate reaction kinetics and mechanisms for polymer modification chemistry Builds on previous CPAC concepts for NeSSI™ as fluidic delivery AND analysis platform for microreactors Includes development and testing of Synovec’s μ-MMS in NeSSI™ 3 years, $718K

NeSSI™ Proposals (cont.) NSF Chemistry Research Instrumentation and Facilities: Instrument Development (CRIF-ID) Provides basic research and testing to characterize NeSSI™ flows and develop needed support sub-systems for utilizing NeSSI™ in laboratory applications Funding to develop 3 (gas, liquid, and student lab) demonstration NeSSI™ systems 3 years, $642K

NeSSI™ Proposals (cont.) NSF Sensors and Sensor Networks Involves using NeSSI™ as a platform for characterizing vapochromatic compounds and development of gas phase sensors 2 identical NeSSI™ systems at UW and UM 3 years, $612K Washington Technology Center (WTC) Development of prototype sensor/actuator manager (SAM) Collaborative effort with Infometrix Phase I, 6 months, $40K

NeSSI™ Fermentation System Switching filter system to handle particulate laden liquid streams Cells in fermentation broth Supplied by Bob Sherman, Circor Interested in plugging, cleaning, and other issues related to bio/pharma applications 2 Filters

Circor FermI Filter System

Building Automated NeSSI™ Swagelok provided 5 pneumatic valves, flow components and pressure transducers Parker providing solenoid pilot valve manifold for actuating pneumatic valves Brooks (Emerson) provided MFC’s and electronics Honeywell providing funds for data I/O and control system Thanks to all these contributions, we are very close to having an automated NeSSI™ system

Current CPAC NeSSI™ system

NeSSI™ Knowledge Network Main topic page divided into 4 sections News and Information Discussion (NeSSI Q&A) Component List Only Manufacturers group may post here Only Manufacturers group may post here Testing and Examples Main NeSSI™ web site NKN can be found at

Component List Sub-topics Page shown from the “Valve, Manual” topic Listing of topics under manual valve main topic Number of posts will correspond to different available components

Component List Page Example post from the component list page URL from Vendor Spec. sheet or link Picture, description, or link to more information Other Vendors are currently working to populate the list with more components

Component List Page

User Self-Registration Allows users to setup accounts Selecting to join “Manufacturers” group will queue user’s registration until a moderator approves it. Membership in other groups automatically approved immediately Profile data will be used for NeSSI™ mailing list Check the options available from the “Edit Profile” link once user activates account Once user submits registration form, they are sent an with instructions for activating their new account Your account is not active till you log in and follow the instructions in the

NKN Conclusion New software and web site ready to be used Thanks to Michelle Cohn, UOP for helping CPAC buy a new server to host NeSSI™ and NKN web sites Site functions well on the new server – much easier to use for both posting and browsing NeSSI Component List is becoming populated Major manufacturers (Parker, Circor, Swagelok) already signed up and starting to supply content Still need to get smaller suppliers to do the same Need to get user community to register and start using it

NeSSI™ Sensor Survey The purpose of this survey is to gather information on the sensors and actuators needed for NeSSI Sample Systems, Analytical Systems, and Cluster Applications. The purpose of this survey is to gather information on the sensors and actuators needed for NeSSI Sample Systems, Analytical Systems, and Cluster Applications. This data will be shared with sensor and instrument vendors to help them prioritize development of the devices needed across industries and applications. This data will be shared with sensor and instrument vendors to help them prioritize development of the devices needed across industries and applications. The more information you can provide, the faster better products and performance can be delivered

NeSSI™ Sensor Survey (cont.) On-line survey form on the CPAC NeSSI™ web site Sensor_Survey.htm Sensor_Survey.htm Questions about condition sensors Are you interested How would you rank their importance Operating ranges Questions about analytical sensors Are you interested How would you rank their importance Operating ranges Questions about actuators Questions about “Clusters” Optional contact information

Sample Survey Questions

NeSSI™ Sensor Survey Results Condition Sensors Analytical Sensors

NeSSI™ Sensor Survey Results ActuatorsClusters 14 of the 21 respondents indicated they would share information with Vendors

NeSSI™ Sensor Survey (cont.) Plan is to continue to solicit responses from users Additions to survey questions or content welcome May expand survey activities to help provide market directions to suppliers Other aspects of NeSSI™ development Applet Software and other issues relate to SAM Applet Software and other issues relate to SAM New opportunities or innovations New opportunities or innovations Need to reach beyond the normal NeSSI™ enthusiasts Combined with the discussion board, surveys provide a valuable resource for both end-users and manufacturers of NeSSI

Summary & Conclusion Automated NeSSI™ ready for development Working spec/prototype design complete Prototypes demonstrated in real applications Resolution of the NeSSI™ bus issue For some laboratory applications Components and systems currently available will immediately work and provide benefits For other applications New components/architecture will be needed to “fit” current lab practices The future holds a lot of promise!!