IMMUNOLOGY Doc. dr Dušan Popadić Doc. dr Miloš Marković Ass. dr Emina Savić Prof. dr Vera Pravica Tel Facebook: Antitelija Limfocitic

Welcome to Immunology Course

Advice for successful learning and passing the exam

Immunology Course (40 hours) Lectures (12 hrs) Practice (Seminars and Labs 28 hrs)

Seminars and Labs during first 14 weeks Lectures during first 12 weeks Seminars, Labs and Lectures are integral parts of the course Student are allowed to be absent on seminar or lab twice during the semester

In addition to these 40 hrs to prepare the exam you will need 60 hours of effective work Preparation for lectures and practice (15 hrs) Preparation of colloquium and final exam (45 hrs) Lectures (12 hrs) Practise (seminars and labs 28 hrs)

References Basic Immunology: Functions and Disorders of the Immune System - Authors: Abbas AK, Lichtman AH. - Publisher: Elsevier - 3 rd edition updated, 2011.ppt presentations and authorised supplementary material (available on web site)

activities on the course (seminars, labs and lectures) – through activity points Continuous assessment colloquium – partial, after every 4 weeks (5 th, 9 th and 13 th week) presence on lectures noted separately

Threshold for a pass is 31 points, max 60 points Test (multiple choice – 1 correct answer out of 4) - first: in the 5 th week - second: in the 9 th week - third: in the 13 th week Colloquium 15 minutes per mini test It consists of 30 questions in total (divided into 3 mini tests) 1 point for each answer, max 30 points Final exam Final test with combined multiple choice and short answer questions

Colloquium score (30%) Final exam mark (60%) Activity on seminars and labs (7%) Regularity of course attendance (3%) Final mark in Immunology

Final mark in Immunology (25%) February session → Final mark in Microbiology (75%) June session → Final mark in Microbiology and Immunology Pass in Immunology is a condition for starting the exam in Microbiology

Introduction to immune system Innate and adaptive immunity Types of adaptive immunity Properties and phases of adaptive immune response Central and peripheral lymphoid organs Lymphocyte recirculation

IMMUNITY INNATE (Natural) (Native) ADAPTIVE (Aquired)

Principle mechanisms of innate and adaptive immunity

Principle mechanisms of innate and adaptive immunity

The most important cells of the immune system

Chain of events in infection

Pathogen(s) enter(s) tissue

Macrophages recognize (and eliminate) pathogens

Inflammation is induced and PMNs attracted

Antigen-presenting cells (APCs) capture antigen(s)

APCs migrate to draining lymph node

T cells are activated by APCs

B cell are activated (helped by T cells)

Activated B cells (plasma cells) produce antibodies (Abs)

Activated T cells and Abs leave lymph node...

... enter blood stream and...

... migrate to site of infection

Activated T cells stimulate phagocytes

Abs neutralize pathogens and stimulate phagocytes

Pathogen is eliminated

Principle mechanisms of innate and adaptive immunity

Mechanisms of adaptive immunity - acquired throughout a lifetime of an individual - result of previous contact with pathogen - present in vertebrates

Properties of adaptive immunity - diversity and specificity - memory - clonal expansion - autotolerance - specialization - stimulation of mechanisms of innate immunity

Types of adaptive immunity

Phases of adaptive immune response

Types of lymphocytes

Lymphoid organs

Lymph node structure

Recirculation of T lymphocytes

The morphology of the spleen

Introduction to immune system Innate and adaptive immunity Types of adaptive immunity Properties and phases of adaptive immune response Central and peripheral lymphoid organs Lymphocyte recirculation

lymph nodes, spleen and MALTj.Primary adaptive immune response begins in 10. peripheral lymphoid organsi.Human peripheral (secondary) lymphoid organs are 9. epithelial barriersh.Human central (primary) lymphoid organs are 8. early defence against infectious agents g.Important properties of adaptive immune cells are 7. bone marrow and thymusf.Types of adaptive immunity are6. diversity, specificity and memorye.Cells of adaptive immunity are5. natural or native immunityd.Cells of innate immunity are4. B and T lymphocytesc.First line of defence of innate immunity is provided by 3. humoral and cellular immunity b. Mechanisms of innate immunity mediate 2. phagocytes and NK cellsa.Innate immunity is also called1. 1._____2._____3._____4._____5._____6._____7._____8._____9._____10.____ d.g.h.a.c.b.e.f.j.i.