Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation.

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Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 1  Immune system itself  Neuro-endocrine system Components of Immune Regulation

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 2  Positive events: Enhancement of immune response.  Negative events: Suppression of immune response. Effects of Immune Regulation

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 3 Ag APCs Th1 Tc B Ab PMN NK Th2 Complement Positive events: Enhancement of immune response. Targetcells MHCCK MHCCK CKs CKs

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 4 Ag APC Th1 Tc B Ab PMN NK Th2 Complement Negative events: Suppression of immune response.Targetcells MHCCK MHCCK CKs CKs Ts

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 5 Ag APCs Th1 Tc B Ab PMN NK Th2 Complement Immune Response(IR) Targetcells MHCCK MHCCK CKs CKs

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 6 Ag concentration

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 7 Ag APC Th1 Tc B Ab PMN NK Th2 Complement Antigen Presentation Targetcells MHCCK MHCCK CKs CKs

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 8 MHC-Ag peptide complex formation ??

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 9 Ag APC Th1 Tc B Ab PMN NK Th2 Complement Immune Response(IR) Targetcells MHCCK MHCCK CKs CKs

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 10 APC Th2Th1 ++ IFNr IL-4/10 Th1 and Th2 balance

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 11

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 12 Ag APC Th1 Tc B Ab PMN NK Th2 Complement Immune Response(IR) Targetcells MHCCK MHCCK CKs CKs Ts

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY CD4 + CD25 + Regulatory T cells Self-reactive T cell CD4+CD25+ Treg cells

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 14

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 15 Suppressive function :  Produce cytokines: IL-10/TGFβ  T-T interaction Functions of CD4 + CD25 + Treg cellsTreg CD4+CD25+ T CD4+CD25- APC

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 16 Functions of CD4 + CD25 + Treg cells Suppressive function :  Produce cytokines: IL-10/TGFβ  Cell-cell contact

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 17 Ag APC Th1 Tc B Ab PMN NK Th2 Complement Immune Response(IR) Targetcells MHCCK MHCCK CKs CKs Ts

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 18 Antibody Production by B cell Th2

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 19 Ag + Ab Antibody response (Humoral immune response) (Humoral immune response)

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 20 Ag + Ab mediated B cell 图 12-1 抗原 - 抗体（ IgG ）复合物交联 BCR 和 Fc  R Ⅱ -B 对 B 细胞抑制作用示意图 B cell

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 21 Ag APC Th1 Tc B Ab PMN NK Th2 Complement Immune Response(IR) Targetcells MHCCK MHCCK CKs CKs Ts

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 22 — Inactivated itself — Regulated by inhibitor Regulation of complement

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 23

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 24  Immune system itself  Neuro-endocrine system Components of Immune Regulation

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 25 Regulations by neuro-endocrine system

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 26 Regulations by neuro-endocrine system

Medical ImmunologyDEPARTMENT OF IMMUNOLOGY 27 Ag APC Th1 Tc B Ab PMN NK Th2 Complement Targetcells MHCCK MHCCK CKs CKs Ts Regulation of immune response