W. Mark Saltzman Yale University Biomaterials, Drug Delivery, and Tissue Engineering

Biomaterials for Controlled Release of Drugs PLGA nanoparticles loaded with camptothecin (CPT). Scale bar: 500 nm. Sawyer, Saucier-Sawyer, Booth, Liu, Patel, Piepmeier, Saltzman (2011) Brem, Colvin, Langer, Saltzman, and Guilford Pharmaceuticals ( ): Gliadel ® approved for glioblastoma multiforme (1996) Sawyer, Saucier-Sawyer, Booth, Liu, Patel, Piepmeier, Saltzman (2011)

Nanoparticles Loaded with Genetic Material DNA: Pharm Res 16:1300, 1999; J Cont Rel 129:66, 2008; Nanomedicine 6:334, 2010; Nature Materials 11:82, 2012 siRNA: Nature Materials 8:526, 2009; Biomaterials 32:6194, 2011; Biomaterials 33:583, 2012 Peptide Nucleic Acids: Molecular Therapy 19:172, 2011 Molecular Pharmaceutics 9:1481, 2012 Zhou, Patel, Fu, Bertram, and Saltzman (2012)

Tissue Engineering: Transplantable materials that turn into vascularized tissues Human endothelial cells Polymer microparticles loaded with proteins that stimulate blood vessel growth Suspend in a Collagen Gel Implant into a location in the body where new blood vessels are needed With Jordan Pober, Immunobiology