Genes and Function: The Rewriting of our Textbooks of Pathology Presented By David Hafler at 2014 ASCO Annual Meeting.

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Presentation transcript:

Genes and Function: The Rewriting of our Textbooks of Pathology Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 2 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 3 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 4 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 5 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 6 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 7 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 8 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 9 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 10 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 11 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 12 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 13 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 14 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 15 Presented By David Hafler at 2014 ASCO Annual Meeting

Glioblastoma multiforme Presented By David Hafler at 2014 ASCO Annual Meeting

Treatments Presented By David Hafler at 2014 ASCO Annual Meeting

WHO Classification Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 19 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 20 Presented By David Hafler at 2014 ASCO Annual Meeting

PD-1 Expression CD4 T effectors in on Glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 22 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 23 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 24 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 25 Presented By David Hafler at 2014 ASCO Annual Meeting

Patient survival linked to Tumor-associated Tregs Presented By David Hafler at 2014 ASCO Annual Meeting

Increase numbers of regulatory T Cells in Glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

Tregs and CD4 T effector cells in glioblastoma are Tim3+PD-1+ Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 29 Presented By David Hafler at 2014 ASCO Annual Meeting

PD-1+Tim3+ Tregs restricted to grade 4 glioblastoma Presented By David Hafler at 2014 ASCO Annual Meeting

Absence of Tim3+PD-1+ Tregs in the blood of healthy controls Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 32 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 33 Presented By David Hafler at 2014 ASCO Annual Meeting

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Blocking monoclonal antibodies increase CD4 T effector proliferation but not Treg suppression Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 37 Presented By David Hafler at 2014 ASCO Annual Meeting

Impaired suppression by GBM-Treg and proliferative response by GBM-Teff Presented By David Hafler at 2014 ASCO Annual Meeting

PD-1+Tim3+ Tregs have decreased suppressor function Presented By David Hafler at 2014 ASCO Annual Meeting

PD-1+ CD4 effector cells and Tregs have shortened telomeres Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 41 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 42 Presented By David Hafler at 2014 ASCO Annual Meeting

Slide 43 Presented By David Hafler at 2014 ASCO Annual Meeting