Appraisal of Guidelines for Research & Evaluation Using the AGREE¹ Instrument CAN-IMPLEMENT Toolkit Version 1.0 April 2010 Modified from:

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Presentation transcript:

Appraisal of Guidelines for Research & Evaluation Using the AGREE¹ Instrument CAN-IMPLEMENT Toolkit Version 1.0 April 2010 Modified from: ¹AGREE Collaboration (2001). Appraisal of guidelines for research & evaluation (AGREE) instrument monograph. Available from:

Guideline Appraisal Process ■ Several appraisal tools exist: (Graham ID, Calder L, Hebert PC, Carter A, Tetroe J. A Comparison of Clinical Practice Guideline Appraisal Instruments. International Journal for Technology Assessment in Health Care. 2000;16(4): ) ■ Appraisal of Guidelines Research and Evaluation (AGREE) ■ ( …becoming the gold standard

AGREE Instrument ■ Developed by an international group of researchers and guideline developers (13 countries) ■ Endorsed by the World Health Organization ■ Provides a framework for assessing the quality of Clinical Practice Guidelines (CPGs) ■ Quality is the confidence that potential biases of the guideline development have been addressed adequately

STRUCTURE 23 items 4 (7) point Likert Scale Overall Assessment User Guide & Manual 1. Scope & purpose (3) 2. Stakeholder involvement (4) 3. Rigour of development (7) 4. Clarity & presentation (4) 5. Applicability (3) 6. Editorial independence (2) SIX Domains

RESPONSE SCALE

DOMAIN 1. SCOPE AND PURPOSE 1.The overall objective(s) of the guideline is(are) specifically described. 2. The clinical question(s) covered by the guideline is(are) specifically described. 3. The patients to whom the guideline is meant to apply are specifically described.

DOMAIN 2. STAKEHOLDER INVOLVEMENT 4. The guideline development group includes individuals from all relevant professional groups. 5. The patients’ views and preferences have been sought. 6. The target users of the guideline are clearly defined. 7. The guideline has been piloted among target users.

DOMAIN 3. RIGOUR OF DEVELOPMENT 8. Systematic methods were used to search for evidence. 9. The criteria for selecting the evidence are clearly described. 10. The methods used for formulating the recommendations are clearly described. 11. The health benefits, side effects and risks have been considered in formulating the recommendations.

DOMAIN 3. RIGOUR OF DEVELOPMENT cont. 12. There is an explicit link between the recommendations and the supporting evidence. 13. The guideline has been externally reviewed by experts prior to its publication. 14. A procedure for updating the guideline is provided.

DOMAIN 4. CLARITY AND PRESENTATION 15. The recommendations are specific and unambiguous. 16. The different options for management of the condition are clearly presented. 17. Key recommendations are easily identifiable. 18. The guideline is supported with tools for application.

DOMAIN 5. APPLICABILITY 19. The potential organisational barriers in applying the guideline have been discussed. 20. The potential costs implications of applying the recommendations have been considered. 21. The guideline presents key review criteria for monitoring and/or audit purposes.

DOMAIN 6. EDITORIAL INDEPENDENCE 22. The guideline is editorially independent from the funding body. 23. Conflicts of interest of guideline development members have been recorded

OVERALL ASSESSMENT Would you recommend these guideline for use in practice? Strongly recommend Recommend (with provisos or alterations) Would not recommend Unsure

OVERALL ASSESSMENT cont. Do not aggregate the six domain scores into a single quality score! Take each appraisal criteria into account Use common sense as well

AGREE CONCLUSIONS  AGREE is the first appraisal instrument for clinical guidelines to be developed and tested internationally  It can be used consistently by a wide range of professionals from different cultural backgrounds  Need several appraisers (4) to assess one guideline  Domain scores should not be aggregated

AGREE UPDATE  The AGREE Instrument bas been translated into 10 European languages  All EU funded projects requested to assess CPGs with AGREE Instrument  WHO has endorsed the AGREE Instrument  Council of Europe formally recommends its use  Becoming the gold standard in guideline appraisal  New release planned 2009 – 7 point scale