Automated Metered Dose Inhaler Presentation #5 (04/07/04) Presented By Group 11: The “MDI Auto-Maniacs” Maria del Carmen Carrillo Jennifer B. Struble Loyrirk Temiyakarn

Problem Definition Automatic Metered Dose Inhalant (MDI) delivery device: Automatic Metered Dose Inhalant (MDI) delivery device: Electromechanical, in-hospital inhalant drug delivery system Electromechanical, in-hospital inhalant drug delivery system Patients are mechanically ventilated and sedated Patients are mechanically ventilated and sedated Medication delivered automatically as prescribed electronically Medication delivered automatically as prescribed electronically Medication must be well shaken (homogenized with propellant) Medication must be well shaken (homogenized with propellant)

Background What is a Metered Dose Inhaler? What is a Metered Dose Inhaler? pocket-sized handheld inhaler delivers standardized dose of medication for bronchodilation Who Uses Them? Who Uses Them? Patients with asthma or chronic obstructive pulmonary disease (COPD) Setting? Setting? Critical patients in hospitals Critical patients in hospitals Prescriptions for outpatient or in-home use Prescriptions for outpatient or in-home use

Current Issues Recent Statistics 1/25 patients are intubated and mechanically ventilated (1997) Methods in-use Manual administration Patent Search Automatic methods are NOT for mechanically ventilated patients Patent Number 6,095,141

Design Factors Integration with existing endotracheal tubing Integration with existing endotracheal tubing Homogenization with propellant Homogenization with propellant Delivery of medication into ventilation system Delivery of medication into ventilation system Tubing length Tubing length Synchronization of delivery with breathing Synchronization of delivery with breathing Software/Automation Software/Automation User interface User interface Prescription error checking Prescription error checking

Shaking = Homogenization Key obstacle - homogenization Key obstacle - homogenization Actuators - homogenize and administer Albuterol Actuators - homogenize and administer Albuterol Pneumatic Pneumatic Simple singular directional motion Simple singular directional motion Set stroke length Set stroke length Controlled through relays/valves by computer Controlled through relays/valves by computer

Experiment on Homogenization  Overall - Difficult to quantify and so based on subjective analysis 1. Soft vs. Vigorous Shakes - Soft more effective 2. Various Vigorous Shakes - One worked better than two 3. Various Soft Shakes - Five better than three or ten 4. With the Spacer - ineffective, has to be inhaled to leave the spacer

Project Status Research completed Ventilators (Siemens Servo I) Ventilation circuits Albuterol canisters Homogenization Parts obtained Festo pneumatics Cylinders Valves Tubing Computer w/ DAQ card Parts still needed Relays Casing/Enclosure Prototype in construction

Working Design: Using Prefabricated Canisters Integrated with existing ventilation circuit Integrated with existing ventilation circuit In-line using AeroChamber In-line using AeroChamber Homogenize Homogenize Pneumatic Actuator Pneumatic Actuator Computer-controlled Computer-controlled LabVIEW LabVIEW Prescribe dosage by timer/alarm Prescribe dosage by timer/alarm Homogenization/actuation sequence programmed Homogenization/actuation sequence programmed Keeps track of actuations, alerts user before new canister is needed Keeps track of actuations, alerts user before new canister is needed

Timeline Completed Work Completed Work Research Research Clearly defined design factors Clearly defined design factors Through Innovation Workbench Through Innovation Workbench Testing with Albuterol Testing with Albuterol Obtained Festo parts Obtained Festo parts Current Work Current Work Obtain more components for prototype Obtain more components for prototype Relays Relays Casing/Enclosure Casing/Enclosure Build prototype Build prototype Timeline Obtain parts ~ on-going Prototype ~ next week Testing ~ next week Final prototype ~ mid-April Poster creation ~ mid- late-April Woo-hoo!

References ml ml ml ml hesia_glossary-05.htm hesia_glossary-05.htm hesia_glossary-05.htm hesia_glossary-05.htm ?page=5 ?page=5 ?page=5 ?page=5 Hudson RCI. AnaConDa™ Principles of Operation Hudson RCI. AnaConDa™ Principles of Operation