Three-component model of anxiety Anxiety Disorders Generalized anxiety disorder Panic attacks Phobias Post-traumatic stress disorder Obsessive-compulive.

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Presentation transcript:

Three-component model of anxiety Anxiety Disorders Generalized anxiety disorder Panic attacks Phobias Post-traumatic stress disorder Obsessive-compulive disorder

Neurotransmitters responsible for anxiety response: GABA Norepinephrine Corticotropin-releasing factor

Early Experience and Stress

Dose-dependent effects of CNS depressants on levels of consciousness

Treating anxiety disorders Anxiolytics – drugs that reduce anxiety Barbiturates (nembutal – pentobarbital) Benzodiazepines (valium – diazepam, rohypnol) Alcohol

Barbiturates –Acute effects Relieves anxiety Produces sleep/anesthesia Loss of judgment etc. High when injected –Chronic effects Increase liver enzymes Rebound excitability effect similar to alcohol

17.9 Margin of safety

Benzodiazepine –Acute effects Relieves anxiety Less loss of judgment etc. Muscle relaxant –Chronic effects Do NOT increase liver enzymes

Drug effects on locus coeruleus cell firing

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