Bioinformatics and Comparative Genome Analyses Course Course web page: EMBO Bioinformatics and Comparative Genome Analyses Course Stazione Zoologica Anton Dohrn, Naples, Italy, May , 2012 EMBO Bioinformatics and Comparative Genome Analyses Course Stazione Zoologica Anton Dohrn, Naples, Italy, May , 2012 Introduction Fredj Tekaia Institut Pasteur

Why this course ?

GOLD: Tree of life total projects: Complete genomes 3173 projects 2079 published 1094 Permanent Drafts (2012/05/02) Ongoing: 7908 Bacteria 213 Archaea 2385 eukaryotes Metagenomes: 334

Evolution of the number of complete genome sequencing projects Complete sequencing genomes span the three domains of life Projects

MathematicsStatistics Nucleotide & protein sequences and related informations Informatics Biology Bioinformatics

The main objectives of the course are to familiarize participants with bioinformatics and large scale genome data analyses skills by introducing: 1- advanced fundamental algorithms used in Bioinformatics; 2- their application in genome analyses; 3- recent knowledge acquired from genomes studies and their perspectives. Bioinformatics and Comparative Genome Analysis

Main Lecture/practical topics include: Genomes comparisons: Technical aspects - writing scripts; - Methods applied to families of genes/proteins: multiple alignments, phylogeny analyses; -Determination of paralogs - orthologs and clustering; - Genome visualization (Circos); - Genomes alignments; Next Generation Sequencing: Methods and Tools; Chip-Seq: Methods and applications; Microarray: Methods for gene expression analyses; Protein-Protein Interactions;

Lectures on specific topics and perspectives: Base composition variability in vertebrate genomes; Realistic Models and Efficient Algorithms in Bioinformatics/Biophysics Analyses of Genomes; Transcriptome mining: examples of meta-analysis using gene expression data; Eukaryotic Genomes and Evolution.

Evening lecture at 8:00 Mme Christiane Groben: Freedom for Research: Anton Dohrn and Science management

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