Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements by Harendra Guturu, Andrew C. Doxey, Aaron M. Wenger,

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Presentation transcript:

Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements by Harendra Guturu, Andrew C. Doxey, Aaron M. Wenger, and Gill Bejerano Philosophical Transactions B Volume 368(1632): December 19, 2013 ©2013 by The Royal Society

Computational approach for prediction of transcription factor (TF) complexes using genomic and structural data. Harendra Guturu et al. Phil. Trans. R. Soc. B 2013;368: ©2013 by The Royal Society

Structural analysis of predicted TF complexes: physical proximity and interaction mechanisms. Harendra Guturu et al. Phil. Trans. R. Soc. B 2013;368: ©2013 by The Royal Society

Detected interactions between DNA-binding domain families and selected structural models of SMAD complexes. Harendra Guturu et al. Phil. Trans. R. Soc. B 2013;368: ©2013 by The Royal Society

Validation of predicted TF complexes and identification of specific TF partners using ChIP-seq data. Harendra Guturu et al. Phil. Trans. R. Soc. B 2013;368: ©2013 by The Royal Society

Detection of a BHLH+{5}BHLH+ complex in genomic regions bound by Tcf3 (BHLH) in mouse T- cell ChIP-seq data. Harendra Guturu et al. Phil. Trans. R. Soc. B 2013;368: ©2013 by The Royal Society