Cancer and LKB1 By: Rosanna Chan, Ria Shome, Chloe Ortbals, Alex Maynard, Michelle Reznikova.

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Presentation transcript:

Cancer and LKB1 By: Rosanna Chan, Ria Shome, Chloe Ortbals, Alex Maynard, Michelle Reznikova

What is Cancer? DNA malignant and benign cancer Current research

What is a Tumor Suppressor? Anti-oncogene Checkpoints Checking energy homeostasis

Energy Homeostasis aka. Metabolic Stress ATP & AMP Anabolic pathways –ATP + small molecules => AMP + large molecule Catabolic pathways –AMP + large molecule => ATP + smaller molecules

AMPK Facts Protein kinase Metabolic stress (anabolic & catabolic)

How is LKB1 a Tumor Suppressor? -LKB1 and AMPK –energy homeostasis (AMP:ATP ) -prevents cell from dividing if there is an imbalance –Cancerous cells If LKB1 is absent the cell divides more often (Peutz Jeghers Syndrome)

Molecular Structure of LKB1 Arg74= reduce catalytic activity -arginine RESIDUES MUTATED IN PJS Interaction with STRAD –CFT [ ]= reduced catalytic activity –c-terminal flanking tail Asp208 Arg74 Thr230 Glu199 Ser232

LKB1-STRAD-MO25 Complex Function

STRAD Molecular Structure - pseudokinase that helps activate LKB1 Leu241 Gln251 Gln286

MO25 Molecular Structure scaffolding protein o Orients the activation loop of LKB1 Phe243 Arg240

How Does LKB1 Affect Us? where it is expressed PJS/Cancer

To Conclude LKB1

Citations "Adenosine Monophosphate." ChemSpider. N.p., n.d. Web. 06 Dec "Case Study: Thermodynamics of ATP." Chemwiki. N.p., n.d. Web. 06 Dec Cell Cycle with Checkpoints. Digital image. N.p., n.d. Web. 5 Dec Hardie, D. Grahame, and Dario Alessi. "LKB1 and AMPK and the cancer-metabolism link - ten years after." BMC Biology. N.p., n.d. Web. 4 Dec Stick Figure. Digital image. Portablestudios. N.p., n.d. Web.. Serine/threonine Kinase 11. Digital image. Wikipedia. N.p., n.d. Web. Van Aalten, Daan, and Elton Zeqiraj. "Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation." ScienceMag. N.p., 5 Nov Web.. "What Is Cancer?" What Is Cancer? N.p., n.d. Web. 04 Dec