Figure 1. Figure 2 ab p=0.0009 p=0.0014 *** Figure 3 a *** b cFos TP53 Beta actin cFos TP53 Beta actin.

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Figure 1

Figure 2 ab p= p=0.0014

*** Figure 3 a *** b cFos TP53 Beta actin cFos TP53 Beta actin

UntreatedCXR9HXR9 Figure 4 b a c ** EA LA % cells ** * *

Figure 5 IC50 (  M) Decreasing sensitivity p= p< **** * Decreasing sensitivity p=0.0243p=0.0008p<0.0001p= *** a b r 2 = p= SKBR3 MB231 MCF7 ZR75.1 UACC MCF10a NBT (predicted) cd

Figure 6 a b c p=0.004 p<0.001 p= CXR9HXR9 S T d

Online resource 1

CXCL FOSB 4.04 ATF AREG 3.61 TNFAIP NR4A NR4A ZFP CD UPP PPP1R15A 2.82 CD CCL EGR ARL TNF 3.21 KLF DUSP IL1RL NCOA * TGATTAAT(G/T)(G/A) Online resource 2 Log fold increase in transcription by HXR9 Base pairs 5’ from transcription start site

a b c d e f Online resource 3 p=0.0126p= p= p=0.8836p= p=0.2378p= h g p= p=0.8344