Pain Day – The Basics of Pain

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Presentation transcript:

Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of Neuroscience Department of Otolaryngology – HNS

Our Senses Share Many Common Properties The IBBS Center for Sensory Biology Randall Reed - olfaction Paul Fuchs - hearing Michael Caterina - Pain/touch Xinzhong Dong - Pain/touch Craig Montell - vision/taste Elisabeth Glowatzki - hearing Jeremy Nathans - vision King-Wai Yau - vision/olfaction Angelika Doetzlhofer – hearing Michael Deans - hearing

Classic View of the Senses The Five Senses - Provide Information Vision Smell Taste Hearing Touch Also Provide Protection

The Spectrum of Sensations Pain from a Broad Perspective: Touch Itch Pain

TRP Channels: Molecular Gatekeepers for the Senses TRP Channels Mediate: Thermal Sensation / Pain Taste Some aspects of: Vision Olfaction Hearing

The Senses: Targets of Environmental Assault Sensory Systems lie at interface between our inner and outer world – Subject to Damage Hearing Loss Burn/Itch Olfactory Loss Light Induced Damage

Key Opportunities/Practical Implications of Advances in Sensory Biology Strategies to modulate (up or down) sensory perception (Pain/Auditory/Chemosensory) Organization/Interaction of cells in tissues Molecular and cellular genesis of specialized organelles Understand processes of neuronal damage, repair and regeneration

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