Skin and Soft Tissue Infections
Vesicles Clinical SyndromeInfectious Agent SmallpoxVariola Virus ChickenpoxVaricella-zoster virus Shingles (herpes zoster)Varicella-zoster virus Cold sores, herpetic whitlow, herpes gladiatorum Herpes simplex virus Hand-foot-and-mouth disease Coxsackie virus OrfParapoxvirus Molluscum ContagiosumPox-like virus RickettsialpoxRickettsia akari Blistering distal dactylitisStaphylococcus aureus or Streptococcus pyogenes
Bullae Clinical SyndromeInfectious Agent Staphylococcal scalded-skin syndrome S. aureus Necrotizing fasciitis S. pyogenes, Clostridium spp., mixed aerobes and anaerobes Gas gangreneClostridium spp. Halophilic vibrioVibrio vulnificus
Crusted lesions Clinical SyndromeInfectious Agent Bullous impetigo/ecthyma S. aureus Impetigo contagiosaS. pyogenes RingwormSuperficial dermatophyte fungi SporotrichosisSporothrix schenckii HistoplasmosisHistoplasma capsulatum CoccidioidomycosisCoccidioides immitis BlastomycosisBlastomyces dermatitidis Cutaneous leishmaniasis Leishmania spp. Cutaneous tuberculosis Mycobacterium tuberculosis NocardiosisNocardia asteroides
Folliculitis Clinical Syndrome Infectious Agent FurunculosisS. aureus Hot-tub folliculitis Pseudomonas aeruginosa Swimmer's itchSchistosoma spp. Acne vulgarisPropionibacterium acnes
Papular and Nodular lesions Clinical SyndromeInfectious Agent Fish-tank or swimming-pool granuloma Mycobacterium marinum Creeping eruption (cutaneous larva migrans) Ancylostoma braziliense DracunculiasisDracunculus medinensis Cercarial dermatitisSchistosoma mansoni Verruca vulgarisHuman papillomaviruses 1, 2, 4 Condylomata acuminata (anogenital warts) Human papillomaviruses 6, 11, 16, 18 Onchocerciasis noduleOnchocerca volvulus Cutaneous myiasisDermatobia hominis Verruca peruanaBartonella bacilliformis Cat-scratch diseaseBartonella henselae Lepromatous leprosyMycobacterium leprae Secondary syphilis (papulosquamous, nodular, and condylomata lata lesions) Treponema pallidum Tertiary syphilis (nodular gummatous lesions) T. pallidum
Ulcer with or without eschars Clinical Syndrome Infectious Agent AnthraxBacillus anthracis Ulceroglandular tularemia Francisella tularensis Bubonic plagueYersinia pestis Buruli ulcerMycobacterium ulcerans LeprosyM. leprae Cutaneous tuberculosis M. tuberculosis ChancroidHaemophilus ducreyi Primary syphilisT. pallidum
Erysipelas Infectious Agent: S. Pyogenes
Cellulitis Infectious Agent: Staphylococcus spp., Streptococcus spp., various other bacteria
Necrotizing fascitiis Clinical SyndromeInfectious Agent Streptococcal gangreneS. pyogenes Fournier's gangreneMixed aerobic and anaerobic bacteria Staphylococcal necrotizing fasciitis Methicillin-resistant S. aureus
Myositis and Myonecrosis Clinical SyndromeInfectious Agent PyomyositisS. aureus Streptococcal necrotizing myositisS. pyogenes Gas gangreneClostridium spp. Nonclostridial (crepitant) myositisMixed aerobic and anaerobic bacteria Synergistic nonclostridial anaerobic myonecrosisMixed aerobic and anaerobic bacteria