Wild Type Drosophila

Ommatidium 8 Photoreceptor cells (R1-R8) 4 Cone cells (secrete lens) 8 Pigment cells

Wild Type Eye Phenotype

Eyeless Mutant Phenotype (hypomorphic allele)

DNA Paired Domain Protein

Figure 1A LacZ No Transcription of LacZ Gal4 Enhancer-Trap Method

Figure 1A LacZ Enhancer that controls expression in specific tissues Gal4 Enhancer-Trap Method

Figure 1A LacZ Tissue-specific Expression of Gal4 Gal4 Enhancer-Trap Method Tissue-specific Expression of LacZ

Figure 1 Eye-Antennal disc wing disc leg disc

Figure 1A LacZ Gal4 Enhancer-Trap Method Enhancer that controls expression in imaginal disc cells Transcription of LacZ in imginal disc cells

Figure 1A Enhancer that controls expression in imaginal disc cells Transcription of eyeless in imginal disc cells

Figure 2

Figure 3

DNA Paired Domain Protein Drosophila ey, mouse Pax-6 (sey) and Human Pax-6 (Aniridia) genes are ~ 94% similar in Paired domain

Enhancer that controls expression in imaginal disc cells Transcription of Pax-6 in imginal disc cells Pax-6 Ectopic Expression of Mouse Pax-6 Gene

Figure 5 Ectopic Expression of Mouse Pax-6 Gene

Aniridia -- Human Pax-6 Mutation Absence of the iris

Xenopus Oocyte Animal Pole Vegetal Pole

Xwnt-11 mRNA Localization Xwnt-11 is Drosophila wingless homogue

Normal Ventralized

Embryo Grafting Experiment

Goosecoid Protein Expression

Embryo Grafting Experiment Inject mRNAs For Chordin etc.

Formation of ventral structures

Normal Dorsalized