Mutational analysis of 35 bladder cancer cell lines using RNA-seq.

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Presentation transcript:

Mutational analysis of 35 bladder cancer cell lines using RNA-seq

RNA-seq Cell lines Genes

Frequently mutated networks in bladder cancer cell lines

Mutations in CBP/p300 network Nonsense Missense Fusion

Mutations in chromatin remodelling genes Nonsense Missense Fusion

Mutations in oncogenic networks Nonsense Missense Fusion

FGFR3 chr BAIAP2L1 chr

Mutations in tumor suppressors Nonsense Missense Fusion

Expression of ER stress response genes in bladder cancer cell lines

XBP1 splicing in bladder cancer cell lines 26nt