Circ D. Case 52  Clinical : Male baby.

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Presentation transcript:

Circ D

Case 52  Clinical : Male baby.

 Most popular diagnosis….

 Myofibromatosis (+/- infantile) 8.39

Case 53  Clinical: Female, 19 years. Vascular polyp on left side of nose.  PGP 9.5 and CD63 = Positive.  S100, Melan A, SMA, Desmin, EMA, MNF116 = Negative.

 Most popular diagnosis…

 Neurothekeoma (+/-cellular) 6.77

Case 54  Clinical: Female, 28 years old. Slowly growing lesion on chest wall.  Immunohistochemistry: Tumour cells in both components of the tumour are positive for CD34. Negative staining for EMA, Desmin, SMA, S100, FXIIIa, CD31.

 Most popular diagnosis…

 DFSP with giant cell fibroblastoma areas 5.59

Case 55  Clinical: Female, 30 years. Lesion on thigh. ?Haemangioma.

 Most popular diagnoses…

 Epithelioid haemangioma 4.46  Cutaneous epithelioid angiomatous nodule 1.23  Microvenular haemangioma 0.95

Case 56  Clinical: Male, 73 years. Multiple nodules on the buttocks. ?Squamous cell carcinoma.

 Most popular diagnosis…

 Scabies (+/- Norwegian) 9.80

Case 57  Clinical: Male, 63 years. ?BCC.

 Most popular diagnosis…

 Cutaneous lymphadenoma 8.71

Case 58  Clinical: Male, 23 years. Lesion right ring finger.  Special stains: Lesional cells - S100 and EMA positive.

 Most popular diagnosis…

Neurothekeoma (+/- myxoid)9.72 Neurothekeoma (+/- myxoid)9.72

Case 59  Clinical: Male, 87 years. Six month history of itchy dermal nodules.  Special stains: Diffuse positivity for CD79a.  Patchy CD20 and Bcl2 positivity.  CD5 and CD10 negative in this population.  Few aggregates of Bcl6 positive cells. CD23 highlights residual FDC networks only.  Prominent CD3 positive population.  Monotypic expression of Lambda light chains

 Most popular diagnosis…

 Marginal zone lymphoma 6.16

Case 60  Clinical: Female, 75 years. Plaque left shin. ?Lichen simplex.

 Most popular diagnosis…

 Hypertrophic lichen planus 7.36

Case 61  Clinical: Male, 69 years. Forehead lesion. ?Lentigo maligna just above left eyebrow

 Most popular diagnosis…

Lentigo maligna melanoma Lentigo maligna melanoma

Case 62  Female, 61 years old. Lesion excision by plastic surgeon with a diagnosis of verrucous epidermal naevus.

 Submitted diagnosis…

 Granular parakeratosis

Case 63  Female, 38 years. Nodule on the sole of the left foot.  Special stains: Cytokeratin, focally EMA and S100 protein positive.  Negative for SMA, HMB45, p63, CD31 and GFAP.  Approximately 10% of the cells show MIB-1 positivity

 Submitted diagnosis…

 Benign adnexal tumour

Case 64  Male, 79 years old.  Generalised thickening of skin, papular like. ?Scleroderma.  History of monoclonal gammopathy (IgG, Kappa)

 Submitted diagnosis…

Scleromyxoedema Scleromyxoedema

Case 65  female 30 yrs. 2 yr history of cyst neck midline.  EMA++ CD34++

 Submitted diagnosis…

 Low grade fibromyxoid sarcoma

Case 66  Clinical: Female large tumour mass at tip of nose infiltrating septum.  Strongly positive TdT, bcl2, CD99, MNF116, CK20.  Negative for CD3, CD20, CD79a, CD10, bcl6, CD34, S100 and MPO

 Submitted diagnosis…

 Merkel cell carcinoma

 The End