Key Research Questions: The University of Wisconsin – Madison Nanoscale Science and Engineering Center Social, Legal and Environmental Impacts of Engineered Nanomaterials (Thrust 4) Maria Powell, Mathilde Colin, Martye Griffin, Jeff Rudd, Frank Pfefferkorn, Kunle Mofolasayo For more information see our web site: edu Are there harmful human exposures in workplaces & the environment? Outlining Key Risk Data Gaps That Challenge Risk Assessors & Government Agencies What are the priority environmental health & occupational safety risk assessment data gaps related to emerging nanotechnologies? What are the priority environmental health & occupational safety risk assessment data gaps related to emerging nanotechnologies? What technical, social, legal, and economic factors shape these data gaps and regulatory capacities to address them—and how so? What technical, social, legal, and economic factors shape these data gaps and regulatory capacities to address them—and how so? How do data gaps affect federal and state regulatory capacities to address environmental issues related to nanotechnology development? How do data gaps affect federal and state regulatory capacities to address environmental issues related to nanotechnology development? Can we build capacity among scientists, regulatory agencies, policymakers, and citizens to proactively address risk data gaps and other regulatory challenges? Can we build capacity among scientists, regulatory agencies, policymakers, and citizens to proactively address risk data gaps and other regulatory challenges? Can we develop effective mechanisms for upstream citizen engagement in nanotechnology development? Can we develop effective mechanisms for upstream citizen engagement in nanotechnology development? How can we measure/monitor engineered nanomaterial emissions in air, water, soil, and workplaces? Will engineered nanomaterials have adverse health effects in humans and wildlife over the long term? How can we maximize nanotechnologies’ benefits while preventing environmental and human health risks? What are the environmental fates of engineered nanomaterials? How are they transformed in water, air, soil? Multi-agency local, state Multi-agency local, state and federal government environmental health & safety working group Developing & testing strategies for Developing & testing strategies for monitoring workplace exposures to nanoparticles Nano Cafes: Nano Cafes: engaging engaging citizens & citizens & scientists scientists Nano Cafes & Nano Risk Resource Websites Nano Cafes & Nano Risk Resource Websites Developing Innovative Mechanisms to Engage Citizens, Scientists & Government Agencies in order to Proactively Address Potential Risks Citizen Education & Engagement with Scientists Research Publications Powell, M. and Kleinman, D Building citizen capacities for participation in technoscientific decision making: The democratic virtues of the consensus conference model. Public Understanding of Science, 17, In Press. Kleinman, D., Powell, M., Grice, J., Adrian, J. and Lobes, C A toolkit for democratizing science and technology policy: the practical mechanics of organizing a consensus conference. Bulletin of Science, Technology & Society, 27, Kleinman, D. and Powell, M Science literacy and civic engagement: Learning from a consensus conference. Rainer Glaser, et al (eds.), Science Communication for All, Sense Publisher, In Press. Powell, M., Griffin, M., and Tai, S Bottom-up risk regulations? How nanotechnology risk data gaps challenge U.S. federal, state, and local regulatory capacities. Accepted in Environmental Management. Griffin, M., Edelstein, G. Meyers, J., Schrank, C., Sukup, L. and Wheat, G Nanotechnology and natural resources: Preparing the department for the present and the future. White paper prepared for Wisconsin DNR. Powell, M New risks, old risks, or no risks? How scientists' standpoints shape their nanotechnology risk frames," Health, Risk, and Society, 9(2), King Heiden, T. Dengler, E., Kao, W. J., Heideman, W., and Peterson, R Developmental toxicity of low generation PAMAM dendrimers in zebrafish: Influence of RGD-conjugation. Toxicology and Applied Pharmacology. Powell, M. and Kanarek, M Nanomaterial health effects, Part 1: Background and current knowledge. Wisconsin Medical Journal, 105(2). Powell, M. and Kanarek, M Nanomaterial health effects, Part 2: Uncertainties and recommendations for the future. Wisconsin Medical Journal, 105(3), Kanarek, M Nanomaterials health effects Part 3: Conclusion--hazardous tissue and the precautionary principle. Wisconsin Medical Journal, 106(1), Rudd, J The Commercialization of Nanoparticles: Shifting Authority over Regulation from Industry to the EPA. Accepted in Columbia Law Review. What types & volumes of engineered nanomaterials are currently being produced? Toxicity LC50 ~ 141 µM Sublethal Effects: Engaging scientists, government agencies & policymakers Thrust 4 Projects Addressing Legal, Regulatory, and Technical Risk Data Gaps and Developing Citizen Engagement Mechanisms Copyright 2005 UW NSEC Toxicology & Environmental Fate Research NSEC Scientists Creating Novel NanomaterialsCd/Se Core QD