Honors Biology Chapter 7 Beyond Mendelian Genetics.

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Presentation transcript:

Honors Biology Chapter 7 Beyond Mendelian Genetics

Many Human Phenotypes Follow Mendelian Pattern One gene / two alleles = 1 trait

Genetic Disorders Rare heritable illnesses Most lethal disorders are recessive

Cystic Fibrosis

Huntington’s Disease – Dominant

Some Deleterious Genes Are Sex-Linked X-linked Recessive – Hemophilia (Bleeders Disease)

Hemophilia

X-linked Dominant Retinitis Pigmentosa

Non-Mendelian Genetics Complex Patterns of Inheritence Traits do not segregate according to Mendel’s Laws – X inactivation – Incomplete Dominance – Codominance – Polygenic Traits Epistasis – Multiple Alleles – Environmental Influences – Others

X-Inactivation

Epistasis

Incomplete Dominance

Codominance

Multiple Alelles

Sex-linked Traits

Polygenic Traits

Gene Linkage

Karyotypes Prepared from blood, bone marrow, amniotic fluid, placenta

Karyotypes

Karyotypes Detect Abnormal #

Karyotypes Detect Structural Defects

Pedigrees