Philippe Marmillot, Ph.D Research Assistant Professor Research Seminar SeriesNovember 8th, 2006 Department of Biochemistry and Molecular Biology Chronic.

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Presentation transcript:

Philippe Marmillot, Ph.D Research Assistant Professor Research Seminar SeriesNovember 8th, 2006 Department of Biochemistry and Molecular Biology Chronic Ethanol Consumption: Understanding The Mechanisms Of Ethanol-induced Hepatic Steatosis And Ethanol-induced Regulation Of Cholesterol Homeostasis Research Scientist Lipid Research Laboratory Veterans Health Administration Medical Center Collaborations and Associates R. Lakshman PhD, R. Redman DDS PhD, M. Gong MD PhD, M. Garige MS, L. Castillo BS, O. Okojie BS ext 7661 (Office)

Alcohol & Liver Protein Trafficking: Role of G-Proteins Objectives & Perspectives In vivo (rats) and in vitro (HepG2 cells lines) studies Co-immunoprecipitation studies rabs 1 & 2 with apoE & transferrin IHC (confocal microscopy) studies of rabs 1 & 2 and apoE & transferrin Postranslational studies, i.e., prenylation and glycosylation CONTROL HepG2 Cells ETHANOL-Treated HepG2 Cells apoE rab2 apoE rab2 Financial Support NIH/NIAAA KO1 Ethanol Treatment Decreases Rab2-ApoE Protein Interaction

Annexin VI is distributed in various subcellular compartments Apolipoprotein E associates with Annexin VI (co-immunoprecipitation) Role of Annexin(s) in Ethanol-Mediated Hepatomegaly Objectives & Perspectives Studies of overexpression (GFP) and silencing (siRNA) of annexins II and VI in relation with apoE or transferrin secretion. Time-lapse microscopy study of protein trafficking in control and ethanol conditions. Financial Support VA Medical Center Pilot grant

Ethanol-Induced Change in HDL Composition and Reverse Cholesterol Transport (RCT) Reconstituted HDL system Financial Support NIH/NIAAA RO1 Objectives & Perspectives Study of ethanol-induced regulation of receptors implicated in cholesterol transport. Extend the study in human to correlate Ethanol consumption, HDL composition and defective RCT.